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ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile), ALS2)

Short Description: The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
More information related to gene ALS2.

Products related to ALS2 Gene:

64 results :

Human ALS2 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5746683
Datasheet
Catalog No. ABIN5746683
Type:
ORF
Application:
Cloning
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
Species:
Human
Synonyms:
als2a, CpipJ_CPIJ008258, CpipJ_CPIJ008260, ALS2, Als2
Insert length:
2439 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human ALS2 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4471985
Datasheet
Catalog No. ABIN4471985
Type:
cDNA
Application:
Protein Expression
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
Species:
Human
Synonyms:
als2a, CpipJ_CPIJ008258, CpipJ_CPIJ008260, ALS2, Als2
Insert length:
2439 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Rat ALS2 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
NCBI Accession:
NM_001013413
Species:
Rat
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5245835
Datasheet
Catalog No. ABIN5245835
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
NCBI Accession:
NM_001013413
Species:
Rat
Synonyms:
als2a, CpipJ_CPIJ008258, CpipJ_CPIJ008260, ALS2, Als2
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Als2
Format:
Viral Particles
Storage:
-80 °C
Mouse ALS2 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
NCBI Accession:
NM_001159948
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5245833
Datasheet
Catalog No. ABIN5245833
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
NCBI Accession:
NM_001159948
Species:
Mouse
Synonyms:
als2a, CpipJ_CPIJ008258, CpipJ_CPIJ008260, ALS2, Als2
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Als2
Format:
Viral Particles
Storage:
-80 °C
Human ALS2 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
NCBI Accession:
NM_020919
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5245831
Datasheet
Catalog No. ABIN5245831
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
NCBI Accession:
NM_020919
Species:
Human
Synonyms:
als2a, CpipJ_CPIJ008258, CpipJ_CPIJ008260, ALS2, Als2
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of ALS2
Format:
Viral Particles
Storage:
-80 °C
Mouse ALS2 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
NCBI Accession:
NM_001159948
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5130392
Datasheet
Catalog No. ABIN5130392
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
NCBI Accession:
NM_001159948
Species:
Mouse
Synonyms:
als2a, CpipJ_CPIJ008258, CpipJ_CPIJ008260, ALS2, Als2
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Als2
Format:
Viral Particles
Storage:
-80 °C
Rat ALS2 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
NCBI Accession:
NM_001013413
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5130394
Datasheet
Catalog No. ABIN5130394
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
NCBI Accession:
NM_001013413
Species:
Rat
Synonyms:
als2a, CpipJ_CPIJ008258, CpipJ_CPIJ008260, ALS2, Als2
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Als2
Format:
Viral Particles
Storage:
-80 °C
Human ALS2 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
NCBI Accession:
NM_020919
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5130390
Datasheet
Catalog No. ABIN5130390
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
NCBI Accession:
NM_020919
Species:
Human
Synonyms:
als2a, CpipJ_CPIJ008258, CpipJ_CPIJ008260, ALS2, Als2
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of ALS2
Format:
Viral Particles
Storage:
-80 °C
Human ALS2 cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4758360
Datasheet
Catalog No. ABIN4758360
Type:
cDNA
Application:
Cloning
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
Species:
Human
Synonyms:
als2a, CpipJ_CPIJ008258, CpipJ_CPIJ008260, ALS2, Als2
Insert length:
2439 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human ALS2 cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4826381
Datasheet
Catalog No. ABIN4826381
Type:
cDNA
Application:
Cloning
Gene:
Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)
Species:
Human
Synonyms:
als2a, CpipJ_CPIJ008258, CpipJ_CPIJ008260, ALS2, Als2
Insert length:
2439 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
    • Mouse
    • Rat
  • Application
    • Protein Expression (PExp)
    • Cloning (Clon)
    • Genome Editing with Engineered Nucleases (GEEN)
    • RNA Interference (RNAi)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • His tag
    • HA tag
    • His-GST
    • His-MBP
    • Myc-DYKDDDDK Tag
    • DYKDDDDK Tag
    • RFP tag
  • Vector Backbone
    • pCMV6-Entry
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pRS
    • pCMV6-AC-GFP
    • pCas-Guide
    • pcDNA3.1+C-(K)-DYK
    • pDONR223
    • pRFP-C-RS
  • Vector
    • Mammalian Expression Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
    • Gateway Cloning Vector
  • Insert
    • cDNA
    • ORF
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Spectinomycin
    • Chloramphenicol
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to ALS2

  • amyotrophic lateral sclerosis 2a (juvenile) (als2a)
  • alsin (CpipJ_CPIJ008258)
  • alsin (CpipJ_CPIJ008260)
  • ALS2, alsin Rho guanine nucleotide exchange factor (ALS2)
  • ALS2, alsin Rho guanine nucleotide exchange factor (Als2)
  • amyotrophic lateral sclerosis 2 (juvenile) (Als2)
  • amyotrophic lateral sclerosis 2 (juvenile) (ALS2)
  • 3222402C23Rik
  • 9430073A21Rik
  • als2
  • ALS2CR6
  • Als2cr6
  • Alsin
  • ALSJ
  • IAHSP
  • mKIAA1563
  • PLSJ
  • si:dkey-33m14.1

Gene-IDs for different species

Protein level used designations for ALS2

  • alsin 2
  • amyotrophic lateral sclerosis 2 (juvenile)
  • alsin
  • alsin-like
  • amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein
  • amyotrophic lateral sclerosis 2 protein
  • amyotrophic lateral sclerosis 2 protein homolog
  • amyotrophic lateral sclerosis protein 2 homolog
  • amyotrophic lateral sclerosis 2 (juvenile) homolog
Other products related to ALS2 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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