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APEX1 (Apurinic/Apyrimidinic Endonuclease 1, APEX1)

Short Description: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene\; all encode the same protein. [provided by RefSeq, Jul 2008].
More information related to gene APEX1.

Products related to APEX1 Gene:

81 results :

Human APEX1 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5732961
Datasheet
Catalog No. ABIN5732961
Type:
ORF
Application:
Cloning
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
Species:
Human
Synonyms:
APEX1, apex1, apex1.L, CNG03640, CNH01280, nth, Spirs_4119, Palpr_0103, Apex1
Insert length:
957 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human APEX1 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5732962
Datasheet
Catalog No. ABIN5732962
Type:
ORF
Application:
Cloning
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
Species:
Human
Synonyms:
APEX1, apex1, apex1.L, CNG03640, CNH01280, nth, Spirs_4119, Palpr_0103, Apex1
Insert length:
957 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human APEX1 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4472121
Datasheet
Catalog No. ABIN4472121
Type:
cDNA
Application:
Protein Expression
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
Species:
Human
Synonyms:
APEX1, apex1, apex1.L, CNG03640, CNH01280, nth, Spirs_4119, Palpr_0103, Apex1
Insert length:
957 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human APEX1 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4472122
Datasheet
Catalog No. ABIN4472122
Type:
cDNA
Application:
Protein Expression
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
Species:
Human
Synonyms:
APEX1, apex1, apex1.L, CNG03640, CNH01280, nth, Spirs_4119, Palpr_0103, Apex1
Insert length:
957 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Rat APEX1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
NCBI Accession:
NM_024148
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5104533
Datasheet
Catalog No. ABIN5104533
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
NCBI Accession:
NM_024148
Species:
Rat
Synonyms:
APEX1, apex1, apex1.L, CNG03640, CNH01280, nth, Spirs_4119, Palpr_0103, Apex1
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Apex1
Format:
Viral Particles
Storage:
-80 °C
Mouse APEX1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
NCBI Accession:
NM_001039138
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5104531
Datasheet
Catalog No. ABIN5104531
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
NCBI Accession:
NM_001039138
Species:
Mouse
Synonyms:
APEX1, apex1, apex1.L, CNG03640, CNH01280, nth, Spirs_4119, Palpr_0103, Apex1
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Apex1
Format:
Viral Particles
Storage:
-80 °C
Human APEX1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
NCBI Accession:
NM_001641
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5104529
Datasheet
Catalog No. ABIN5104529
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
NCBI Accession:
NM_001641
Species:
Human
Synonyms:
APEX1, apex1, apex1.L, CNG03640, CNH01280, nth, Spirs_4119, Palpr_0103, Apex1
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of APEX1
Format:
Viral Particles
Storage:
-80 °C
Human APEX1 cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4826575
Datasheet
Catalog No. ABIN4826575
Type:
cDNA
Application:
Cloning
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
Species:
Human
Synonyms:
APEX1, apex1, apex1.L, CNG03640, CNH01280, nth, Spirs_4119, Palpr_0103, Apex1
Insert length:
957 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human APEX1 cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4826574
Datasheet
Catalog No. ABIN4826574
Type:
cDNA
Application:
Cloning
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
Species:
Human
Synonyms:
APEX1, apex1, apex1.L, CNG03640, CNH01280, nth, Spirs_4119, Palpr_0103, Apex1
Insert length:
957 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human APEX1 cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4758496
Datasheet
Catalog No. ABIN4758496
Type:
cDNA
Application:
Cloning
Gene:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)
Species:
Human
Synonyms:
APEX1, apex1, apex1.L, CNG03640, CNH01280, nth, Spirs_4119, Palpr_0103, Apex1
Insert length:
957 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • OriGene
    • antibodies-online
    • ProteoGenix
    • GenScript
  • Reactivity
    • Human
    • Rat
    • Mouse
  • Cited in publications
  • Application
    • Protein Expression (PExp)
    • Cloning (Clon)
    • RNA Interference (RNAi)
    • Genome Editing with Engineered Nucleases (GEEN)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • Myc-DYKDDDDK Tag
    • His tag
    • HA tag
    • His-GST
    • His-MBP
    • RFP tag
    • DYKDDDDK Tag
  • Vector Backbone
    • pCMV6-Entry
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-AC-GFP
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pRS
    • pCMV6-AC
    • pCas-Guide
    • pDONR223
    • pRFP-C-RS
    • pCMV6-XL4
    • pCMV6-XL5
    • pcDNA3.1+C-(K)-DYK
  • Vector
    • Lentiviral Vector
    • Mammalian Expression Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
    • Gateway Cloning Vector
  • Insert
    • ORF
    • cDNA
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • CMV Promoter
    • U6 Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to APEX1

  • apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1)
  • APEX nuclease (multifunctional DNA repair enzyme) 1 (apex1)
  • APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog (apex1.L)
  • DNA-(apurinic or apyrimidinic site) lyase (CNG03640)
  • DNA-(apurinic or apyrimidinic site) lyase (CNH01280)
  • DNA-(apurinic or apyrimidinic site) lyase (nth)
  • DNA-(apurinic or apyrimidinic site) lyase (Spirs_4119)
  • DNA-(apurinic or apyrimidinic site) lyase (Palpr_0103)
  • apurinic/apyrimidinic endodeoxyribonuclease 1 (Apex1)
  • apurinic/apyrimidinic endonuclease 1 (Apex1)
  • APE
  • APE1
  • APEN
  • APEX
  • Apex
  • apex1
  • apex1a
  • APX
  • BAP1
  • HAP1
  • hm:zehn1532
  • MGC76280
  • MGC78928
  • MGC79645
  • REF-1
  • Ref-1
  • REF1
  • wu:fc13d11
  • zgc:66204

Gene-IDs for different species

Protein level used designations for APEX1

  • DNA-(apurinic or apyrimidinic site) lyase
  • APEX nuclease 1
  • APEX nuclease (multifunctional DNA repair enzyme) 1
  • AP endonuclease class I
  • AP lyase
  • apurinic-apyrimidinic endonuclease 1
  • apurinic/apyrimidinic (abasic) endonuclease
  • deoxyribonuclease (apurinic or apyrimidinic)
  • protein REF-1
  • redox factor-1
  • AP endonuclease 1
  • APEN
  • apurinic/apyrimidinic endonuclease 1
  • apurinic/apyrimidinic endonuclease
  • zap1
  • Apurinic-apyrimidinic endonuclease 1
  • Redox factor-1
  • APEX nuclease
Other products related to APEX1 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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