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CDT2/RAMP (Denticleless E3 Ubiquitin Protein Ligase Homolog, DTL)

Short Description: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).
More information related to gene CDT2/RAMP.

Products related to CDT2/RAMP Gene:

55 results :

Human DTL ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5764049
Datasheet
Catalog No. ABIN5764049
Type:
ORF
Application:
Cloning
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
Species:
Human
Synonyms:
DTL, Dtl, dtl.S, dtl
Insert length:
2193 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human DTL ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5764050
Datasheet
Catalog No. ABIN5764050
Type:
ORF
Application:
Cloning
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
Species:
Human
Synonyms:
DTL, Dtl, dtl.S, dtl
Insert length:
2193 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human DTL cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4474906
Datasheet
Catalog No. ABIN4474906
Type:
cDNA
Application:
Protein Expression
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
Species:
Human
Synonyms:
DTL, Dtl, dtl.S, dtl
Insert length:
2193 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human DTL cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4474907
Datasheet
Catalog No. ABIN4474907
Type:
cDNA
Application:
Protein Expression
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
Species:
Human
Synonyms:
DTL, Dtl, dtl.S, dtl
Insert length:
2193 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Mouse DTL CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
NCBI Accession:
NM_029766
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5280167
Datasheet
Catalog No. ABIN5280167
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
NCBI Accession:
NM_029766
Species:
Mouse
Synonyms:
DTL, Dtl, dtl.S, dtl
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Dtl
Format:
Viral Particles
Storage:
-80 °C
Human DTL CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
NCBI Accession:
NM_016448
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5280165
Datasheet
Catalog No. ABIN5280165
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
NCBI Accession:
NM_016448
Species:
Human
Synonyms:
DTL, Dtl, dtl.S, dtl
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of DTL
Format:
Viral Particles
Storage:
-80 °C
Mouse DTL CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
NCBI Accession:
NM_029766
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5164580
Datasheet
Catalog No. ABIN5164580
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
NCBI Accession:
NM_029766
Species:
Mouse
Synonyms:
DTL, Dtl, dtl.S, dtl
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Dtl
Format:
Viral Particles
Storage:
-80 °C
Human DTL CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
NCBI Accession:
NM_016448
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5164578
Datasheet
Catalog No. ABIN5164578
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
NCBI Accession:
NM_016448
Species:
Human
Synonyms:
DTL, Dtl, dtl.S, dtl
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of DTL
Format:
Viral Particles
Storage:
-80 °C
Human DTL cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4761281
Datasheet
Catalog No. ABIN4761281
Type:
cDNA
Application:
Cloning
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
Species:
Human
Synonyms:
DTL, Dtl, dtl.S, dtl
Insert length:
2193 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human DTL cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4761282
Datasheet
Catalog No. ABIN4761282
Type:
cDNA
Application:
Cloning
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
Species:
Human
Synonyms:
DTL, Dtl, dtl.S, dtl
Insert length:
2193 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
    • Mouse
  • Application
    • Protein Expression (PExp)
    • Cloning (Clon)
    • RNA Interference (RNAi)
    • Genome Editing with Engineered Nucleases (GEEN)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • Myc-DYKDDDDK Tag
    • His tag
    • DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • RFP tag
  • Vector Backbone
    • pCMV6-Entry
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pcDNA3.1+C-(K)-DYK
    • pCas-Guide
    • pDONR223
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pRFP-C-RS
    • pRS
    • pCMV6-AC-GFP
    • pCMV6-XL5
  • Vector
    • Mammalian Expression Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
    • Gateway Cloning Vector
  • Insert
    • cDNA
    • ORF
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to CDT2/RAMP

  • denticleless E3 ubiquitin protein ligase homolog (DTL)
  • denticleless E3 ubiquitin protein ligase (Dtl)
  • denticleless E3 ubiquitin protein ligase homolog (Dtl)
  • denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S)
  • denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl)
  • 2810047L02Rik
  • 5730564G15Rik
  • cb151
  • CDT2
  • cdt2
  • cdt2-a
  • chunp6871
  • DCAF2
  • dcaf2
  • L2DTL
  • l2dtl
  • RAMP
  • Ramp
  • ramp
  • RGD1310439
  • wu:fb54b02

Gene-IDs for different species

Protein level used designations for CDT2/RAMP

  • DDB1 and CUL4 associated factor 2
  • DDB1- and CUL4-associated factor 2
  • RA regulated nuclear matrix associated protein
  • RA-regulated nuclear matrix-associated protein
  • denticleless homolog
  • denticleless protein homolog
  • lethal(2) denticleless protein homolog
  • retinoic acid-regulated nuclear matrix-associated protein
  • Meth A ramp
  • meth A retinoic acid-regulated nuclear matrix-associated protein
  • retinoic-acid regulated nuclear matrix-associated protein
  • denticleless protein homolog A
Other products related to CDT2/RAMP such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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