CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal), CHRNA7)
Short Description: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].
More information related to gene CHRNA7.
More information related to gene CHRNA7.
Products related to CHRNA7 Gene:
Recommended next Filters:
60 results :
ORF
Clon
Cloning Vector
pORF
Spectinomycin
unconjugated
Transient
- Type:
- ORF
- Application:
- Cloning
- Gene:
- Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7)
- Species:
- Human
- Vector type:
- Cloning Vector
- Vector backbone:
- pORF
- Resistance Gene:
- Spectinomycin
- Expression:
- Transient
cDNA
PExp
Mammalian Expression Vector
pPM-C-HA
Kanamycin
CMV Promoter
HA tag
Stable
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pPM-C-HA
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- HA tag
- Expression:
- Stable, Transient
gRNA + Cas9
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA + Cas9
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7)
- NCBI Accession:
- NM_012832
- Species:
- Rat
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter, SFFV Promoter
- Expression:
- Stable, Transient
gRNA + Cas9
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA + Cas9
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7)
- NCBI Accession:
- NM_007390
- Species:
- Mouse
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter, SFFV Promoter
- Expression:
- Stable, Transient
gRNA + Cas9
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA + Cas9
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7)
- NCBI Accession:
- NM_000746
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter, SFFV Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7)
- NCBI Accession:
- NM_012832
- Species:
- Rat
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7)
- NCBI Accession:
- NM_007390
- Species:
- Mouse
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7)
- NCBI Accession:
- NM_000746
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
cDNA
Clon
Bacterial Expression Vector
pPB-N-His
Kanamycin
T7 Promoter
His tag
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-N-His
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His tag
- Expression:
- Transient
cDNA
Clon
Bacterial Expression Vector
pPB-His-GST
Kanamycin
T7 Promoter
His-GST
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-His-GST
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His-GST
- Expression:
- Transient
Synonyms and alternative names related to CHRNA7
- cholinergic receptor nicotinic alpha 7 subunit (CHRNA7)
- neuronal acetylcholine receptor subunit alpha-7 (LOC100374356)
- cholinergic receptor, nicotinic, alpha 7 (neuronal) (chrna7)
- cholinergic receptor, nicotinic, alpha polypeptide 7 (Chrna7)
- cholinergic receptor nicotinic alpha 7 subunit (Chrna7)
- cholinergic receptor, nicotinic, alpha 7 (CHRNA7)
- neuronal acetylcholine receptor subunit alpha-7 (LOC100060521)
- Acra7
- alpha7
- BTX
- CHRNA7
- CHRNA7-2
- dZ70B1.1
- NACHRA7
- nAChRa7
- NARAD
Gene-IDs for different species
Protein level used designations for CHRNA7
- a7 nicotinic acetylcholine receptor
- alpha 7 neuronal nicotinic acetylcholine receptor
- alpha-7 nicotinic cholinergic receptor subunit
- cholinergic receptor, nicotinic, alpha polypeptide 7
- neuronal acetylcholine receptor protein, alpha-7 chain
- neuronal acetylcholine receptor subunit alpha-7
- cholinergic receptor, nicotinic, alpha 7
- neuronal acetylcholine receptor subunit alpha-7-like
- acetylcholine receptor alpha 7 neural
- alpha7 nicotinic receptor
- alpha7-nAChR
- C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
- C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
- bungarotoxin alpha
- neuronal nicotinic acetycholine receptor alpha 7
- nicotinic receptor alpha 7 subunit
- cholinergic receptor nicotinic alpha 7
- alpha 7 nicotinic acetylcholine receptor
- nicotinic acetylcholine receptor alpha7
- CHRNA7-FAM7A fusion protein
- cholinergic receptor, nicotinic, alpha 7 (neuronal)
Proteomics products related to CHRNA7 Gene
Other products related to CHRNA7 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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