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Cullin 1 (Cullin 1, CUL1)

Short Description: Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'\; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110 (By similarity).
More information related to gene Cullin 1.

Products related to Cullin 1 Gene:

65 results :

Human CUL1 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Cullin 1 (CUL1)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5733614
Datasheet
Catalog No. ABIN5733614
Type:
ORF
Application:
Cloning
Gene:
Cullin 1 (CUL1)
Species:
Human
Synonyms:
CUL1, LOC100282292, cul1, ATEG_00491, EDI_072700, EDI_264400, SJAG_02591, BDBG_03785, Cul1, cul1a, cul1.S, cul-1, cul1b
Insert length:
1389 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human CUL1 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Cullin 1 (CUL1)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5733615
Datasheet
Catalog No. ABIN5733615
Type:
ORF
Application:
Cloning
Gene:
Cullin 1 (CUL1)
Species:
Human
Synonyms:
CUL1, LOC100282292, cul1, ATEG_00491, EDI_072700, EDI_264400, SJAG_02591, BDBG_03785, Cul1, cul1a, cul1.S, cul-1, cul1b
Insert length:
2331 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human CUL1 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Cullin 1 (CUL1)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4474411
Datasheet
Catalog No. ABIN4474411
Type:
cDNA
Application:
Protein Expression
Gene:
Cullin 1 (CUL1)
Species:
Human
Synonyms:
CUL1, LOC100282292, cul1, ATEG_00491, EDI_072700, EDI_264400, SJAG_02591, BDBG_03785, Cul1, cul1a, cul1.S, cul-1, cul1b
Insert length:
1389 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Rat CUL1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Cullin 1 (CUL1)
NCBI Accession:
NM_001108627
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5081044
Datasheet
Catalog No. ABIN5081044
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Cullin 1 (CUL1)
NCBI Accession:
NM_001108627
Species:
Rat
Synonyms:
CUL1, LOC100282292, cul1, ATEG_00491, EDI_072700, EDI_264400, SJAG_02591, BDBG_03785, Cul1, cul1a, cul1.S, cul-1, cul1b
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Cul1
Format:
Viral Particles
Storage:
-80 °C
Mouse CUL1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Cullin 1 (CUL1)
NCBI Accession:
NM_012042
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5081042
Datasheet
Catalog No. ABIN5081042
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Cullin 1 (CUL1)
NCBI Accession:
NM_012042
Species:
Mouse
Synonyms:
CUL1, LOC100282292, cul1, ATEG_00491, EDI_072700, EDI_264400, SJAG_02591, BDBG_03785, Cul1, cul1a, cul1.S, cul-1, cul1b
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Cul1
Format:
Viral Particles
Storage:
-80 °C
Human CUL1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Cullin 1 (CUL1)
NCBI Accession:
NM_003592
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5081040
Datasheet
Catalog No. ABIN5081040
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Cullin 1 (CUL1)
NCBI Accession:
NM_003592
Species:
Human
Synonyms:
CUL1, LOC100282292, cul1, ATEG_00491, EDI_072700, EDI_264400, SJAG_02591, BDBG_03785, Cul1, cul1a, cul1.S, cul-1, cul1b
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of CUL1
Format:
Viral Particles
Storage:
-80 °C
Human CUL1 cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
Cullin 1 (CUL1)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4760786
Datasheet
Catalog No. ABIN4760786
Type:
cDNA
Application:
Cloning
Gene:
Cullin 1 (CUL1)
Species:
Human
Synonyms:
CUL1, LOC100282292, cul1, ATEG_00491, EDI_072700, EDI_264400, SJAG_02591, BDBG_03785, Cul1, cul1a, cul1.S, cul-1, cul1b
Insert length:
1389 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human CUL1 cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
Cullin 1 (CUL1)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4829724
Datasheet
Catalog No. ABIN4829724
Type:
cDNA
Application:
Cloning
Gene:
Cullin 1 (CUL1)
Species:
Human
Synonyms:
CUL1, LOC100282292, cul1, ATEG_00491, EDI_072700, EDI_264400, SJAG_02591, BDBG_03785, Cul1, cul1a, cul1.S, cul-1, cul1b
Insert length:
1389 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human CUL1 cDNA Clone in Bacterial Expression Vector (His-MBP)
cDNA Clon Bacterial Expression Vector pPB-His-MBP Kanamycin T7 Promoter His-MBP Transient
Type:
cDNA
Application:
Cloning
Gene:
Cullin 1 (CUL1)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Catalog No. ABIN4700595
Datasheet
Catalog No. ABIN4700595
Type:
cDNA
Application:
Cloning
Gene:
Cullin 1 (CUL1)
Species:
Human
Synonyms:
CUL1, LOC100282292, cul1, ATEG_00491, EDI_072700, EDI_264400, SJAG_02591, BDBG_03785, Cul1, cul1a, cul1.S, cul-1, cul1b
Insert length:
1389 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Sequencing Primer:
  • MBP Forward primer: 5'-CGCAGATGTCCGCTTTCTGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human CUL1 cDNA Clone in Mammalian Expression Vector (His tag)
cDNA PExp Mammalian Expression Vector pPM-C-His Kanamycin CMV Promoter His tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Cullin 1 (CUL1)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-His
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
His tag
Expression:
Stable, Transient
Catalog No. ABIN4435506
Datasheet
Catalog No. ABIN4435506
Type:
cDNA
Application:
Protein Expression
Gene:
Cullin 1 (CUL1)
Species:
Human
Synonyms:
CUL1, LOC100282292, cul1, ATEG_00491, EDI_072700, EDI_264400, SJAG_02591, BDBG_03785, Cul1, cul1a, cul1.S, cul-1, cul1b
Insert length:
1389 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-His
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
His tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • ProteoGenix
    • GenScript
  • Reactivity
    • Human
    • Mouse
    • Rat
  • Cited in publications
  • Application
    • Protein Expression (PExp)
    • Cloning (Clon)
    • RNA Interference (RNAi)
    • Genome Editing with Engineered Nucleases (GEEN)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • His tag
    • Myc-DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • RFP tag
    • DYKDDDDK Tag
  • Vector Backbone
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-Entry
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pRS
    • pCas-Guide
    • pDONR223
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pRFP-C-RS
    • pCMV6-AC-GFP
    • pCMV6-XL5
    • pcDNA3.1+C-(K)-DYK
  • Vector
    • Lentiviral Vector
    • Mammalian Expression Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
    • Gateway Cloning Vector
  • Insert
    • cDNA
    • ORF
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • T7 Promoter
    • PGK Promoter
    • SFFV Promoter
    • Enhanced CMV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to Cullin 1

  • cullin 1 (CUL1)
  • cullin-1 (LOC100282292)
  • cullin 1 (cul1)
  • cullin-1 (ATEG_00491)
  • cullin-1 (EDI_072700)
  • cullin-1 (EDI_264400)
  • Cullin 1 (SJAG_02591)
  • Cullin-1 (BDBG_03785)
  • cullin 1 (Cul1)
  • cullin 1a (cul1a)
  • cullin 1 S homeolog (cul1.S)
  • Cullin-1 (cul-1)
  • cullin 1b (cul1b)
  • ATCUL1
  • AUXIN RESISTANT 6
  • AXR6
  • Cul-1
  • Cul1
  • cul1
  • Cullin-1
  • cullin-1
  • cullin 1
  • LOC100282292
  • T10P11.26
  • T10P11_26
  • wu:fc13a10
  • wu:fi43h07
  • wu:fj43a08
  • zgc:55483
  • zgc:55747
  • zgc:77500
  • zgc:111899

Gene-IDs for different species

Protein level used designations for Cullin 1

  • CUL-1
  • cullin-1
  • Cullin-1
  • Cell division control 53 homolog
Other products related to Cullin 1 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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