DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58, DHX58)
Short Description: Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
More information related to gene DHX58.
More information related to gene DHX58.
Products related to DHX58 Gene:
Recommended next Filters:
56 results :
ORF
Clon
Cloning Vector
pORF
Spectinomycin
unconjugated
Transient
- Type:
- ORF
- Application:
- Cloning
- Gene:
- DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58)
- Species:
- Human
- Vector type:
- Cloning Vector
- Vector backbone:
- pORF
- Resistance Gene:
- Spectinomycin
- Expression:
- Transient
ORF
Clon
Cloning Vector
pORF
Spectinomycin
unconjugated
Transient
- Type:
- ORF
- Application:
- Cloning
- Gene:
- DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58)
- NCBI Accession:
- NM_030150
- Species:
- Mouse
- Vector type:
- Cloning Vector
- Vector backbone:
- pORF
- Resistance Gene:
- Spectinomycin
- Expression:
- Transient
cDNA
PExp
Mammalian Expression Vector
pPM-C-HA
Kanamycin
CMV Promoter
HA tag
Stable
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pPM-C-HA
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- HA tag
- Expression:
- Stable, Transient
cDNA
PExp
Mammalian Expression Vector
pPM-C-HA
Kanamycin
CMV Promoter
HA tag
Stable
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58)
- NCBI Accession:
- NM_030150
- Species:
- Mouse
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pPM-C-HA
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- HA tag
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58)
- NCBI Accession:
- NM_001098788
- Species:
- Rat
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58)
- NCBI Accession:
- NM_030150
- Species:
- Mouse
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58)
- NCBI Accession:
- NM_024119
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
cDNA
Clon
Bacterial Expression Vector
pPB-N-His
Kanamycin
T7 Promoter
His tag
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-N-His
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His tag
- Expression:
- Transient
cDNA
Clon
Bacterial Expression Vector
pPB-His-GST
Kanamycin
T7 Promoter
His-GST
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58)
- NCBI Accession:
- NM_030150
- Species:
- Mouse
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-His-GST
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His-GST
- Expression:
- Transient
cDNA
Clon
Bacterial Expression Vector
pPB-His-GST
Kanamycin
T7 Promoter
His-GST
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-His-GST
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His-GST
- Expression:
- Transient
Synonyms and alternative names related to DHX58
- DEXH-box helicase 58 L homeolog (dhx58.L)
- DExH-box helicase 58 (DHX58)
- DExH-box helicase 58 (dhx58)
- probable ATP-dependent RNA helicase DHX58 (LOC100566102)
- DEXH (Asp-Glu-X-His) box polypeptide 58 (dhx58)
- DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58)
- DEXH-box helicase 58 (Dhx58)
- B430001I08Rik
- D11LGP2
- D11lgp2e
- D11Lgp2e
- DHX58
- lgp2
- LGP2
- Lgp2
- LPG2
- MGC82787
- RGD1310093
- RLR-3
Gene-IDs for different species
Protein level used designations for DHX58
- DEXH (Asp-Glu-X-His) box polypeptide 58
- probable ATP-dependent RNA helicase DHX58
- probable ATP-dependent RNA helicase DHX58-like
- Probable ATP-dependent RNA helicase DHX58
- RIG-I-like receptor 3
- RIG-I-like receptor LGP2
- RLR
- RNA helicase LGP2
- ortholog of mouse D11lgp2
- probable ATP-dependent helicase LGP2
- protein D11Lgp2 homolog
- RIG-I-like receptor Lgp2
- protein D11Lgp2
- ATP-dependent RNA helicase DHX58
Proteomics products related to DHX58 Gene
Other products related to DHX58 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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