GNAS (GNAS Complex Locus, GNAS)
Short Description: This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012].
More information related to gene GNAS.
More information related to gene GNAS.
Products related to GNAS Gene:
Recommended next Filters:
118 results :
ORF
Clon
Cloning Vector
pORF
Spectinomycin
unconjugated
Transient
- Type:
- ORF
- Application:
- Cloning
- Gene:
- GNAS Complex Locus (GNAS)
- Species:
- Human
- Vector type:
- Cloning Vector
- Vector backbone:
- pORF
- Resistance Gene:
- Spectinomycin
- Expression:
- Transient
ORF
Clon
Cloning Vector
pORF
Spectinomycin
unconjugated
Transient
- Type:
- ORF
- Application:
- Cloning
- Gene:
- GNAS Complex Locus (GNAS)
- Species:
- Human
- Vector type:
- Cloning Vector
- Vector backbone:
- pORF
- Resistance Gene:
- Spectinomycin
- Expression:
- Transient
cDNA
PExp
Bacterial Expression Vector
pPB-His-GST
Kanamycin
T7 Promoter
His-GST
Transient
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- GNAS Complex Locus (GNAS)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-His-GST
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His-GST
- Expression:
- Transient
cDNA
PExp
Bacterial Expression Vector
pPB-His-MBP
Kanamycin
T7 Promoter
His-MBP
Transient
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- GNAS Complex Locus (GNAS)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-His-MBP
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His-MBP
- Expression:
- Transient
cDNA
PExp
Mammalian Expression Vector
pPM-C-HA
Kanamycin
CMV Promoter
HA tag
Stable
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- GNAS Complex Locus (GNAS)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pPM-C-HA
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- HA tag
- Expression:
- Stable, Transient
cDNA
PExp
Mammalian Expression Vector
pPM-C-HA
Kanamycin
CMV Promoter
HA tag
Stable
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- GNAS Complex Locus (GNAS)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pPM-C-HA
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- HA tag
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- GNAS Complex Locus (GNAS)
- NCBI Accession:
- NM_001159653
- Species:
- Rat
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- GNAS Complex Locus (GNAS)
- NCBI Accession:
- NM_001077510
- Species:
- Mouse
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- GNAS Complex Locus (GNAS)
- NCBI Accession:
- NM_000516
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
cDNA
Clon
Bacterial Expression Vector
pPB-N-His
Kanamycin
T7 Promoter
His tag
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- GNAS Complex Locus (GNAS)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-N-His
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His tag
- Expression:
- Transient
Synonyms and alternative names related to GNAS
- GNAS complex locus (GNAS)
- guanine nucleotide-binding protein G(s) subunit alpha (LOC694289)
- guanine nucleotide-binding protein G(s) subunit alpha (LOC469986)
- GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas)
- GNAS complex locus S homeolog (gnas.S)
- GNAS complex locus (Gnas)
- GNAS complex locus (gnas)
- neuroendocrine secretory protein 55-like (LOC100346323)
- guanine nucleotide-binding protein G(s) subunit alpha (LOC100442753)
- guanine nucleotide-binding protein G(s) subunit alpha (LOC100732436)
- 5530400H20Rik
- A930027G11Rik
- AHO
- C20orf45
- C130027O20Rik
- G-alpha-S
- G-alpha-s
- Galphas
- gnal
- GNAS
- Gnas
- gnas-a
- GNAS1
- Gnas1
- Gnasxl
- Gnpas
- GPSA
- GSA
- Gsa
- GSP
- NESP
- Nesp
- Nesp55
- Nespl
- Oed-Sml
- Oedsml
- P1
- P2
- P3
- PHP1A
- PHP1B
- PHP1C
- POH
- PORGSA1
Gene-IDs for different species
Protein level used designations for GNAS
- adenylate cyclase-stimulating G alpha protein
- alternative gene product encoded by XL-exon
- extra large alphas protein
- guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1
- guanine nucleotide regulatory protein
- guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
- neuroendocrine secretory protein
- protein ALEX
- secretogranin VI
- GNAS complex locus
- GTP-binding regulatory protein alpha subunit exon 1
- guanine nucleotide binding protein, alpha stimulating activity polypeptide 1
- guanine nucleotide-binding protein G(s) subunit alpha
- stimulatory GTP binding protein
- alpha-stimulatory subunit of GTP-binding protein
- guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1
- Gs alpha subunit
- neuroendocrine secretory protein 55
- stimulatory G-protein alpha subunit
- guanine nucleotide-binding protein G(s) subunit alpha isoforms
- G-alpha-8
- GNAS
- GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
- guanine nucleotide binding protein alpha s
- guanine nucleotide-binding protein G-s, alpha subunit
- guanine nucleotide binding protein, alpha stimulating, olfactory type
- guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like
- Galpha s
Proteomics products related to GNAS Gene
Other products related to GNAS such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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