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HLA-DRB5 (Major Histocompatibility Complex, Class II, DR beta 5, HLA-DRB5)

Short Description: HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].
More information related to gene HLA-DRB5.

Products related to HLA-DRB5 Gene:

14 results :

Human HLA-DRB5 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5767811
Datasheet
Catalog No. ABIN5767811
Type:
ORF
Application:
Cloning
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
Species:
Human
Synonyms:
HLA-DRB5
Insert length:
801 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human HLA-DRB5 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4476582
Datasheet
Catalog No. ABIN4476582
Type:
cDNA
Application:
Protein Expression
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
Species:
Human
Synonyms:
HLA-DRB5
Insert length:
801 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human HLA-DRB5 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
NCBI Accession:
NM_002125
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5288277
Datasheet
Catalog No. ABIN5288277
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
NCBI Accession:
NM_002125
Species:
Human
Synonyms:
HLA-DRB5
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of HLA-DRB5
Format:
Viral Particles
Storage:
-80 °C
Human HLA-DRB5 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
NCBI Accession:
NM_002125
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5172682
Datasheet
Catalog No. ABIN5172682
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
NCBI Accession:
NM_002125
Species:
Human
Synonyms:
HLA-DRB5
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of HLA-DRB5
Format:
Viral Particles
Storage:
-80 °C
Human HLA-DRB5 cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4832971
Datasheet
Catalog No. ABIN4832971
Type:
cDNA
Application:
Cloning
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
Species:
Human
Synonyms:
HLA-DRB5
Insert length:
801 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human HLA-DRB5 cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4762957
Datasheet
Catalog No. ABIN4762957
Type:
cDNA
Application:
Cloning
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
Species:
Human
Synonyms:
HLA-DRB5
Insert length:
801 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human HLA-DRB5 cDNA Clone in Bacterial Expression Vector (His-MBP)
cDNA Clon Bacterial Expression Vector pPB-His-MBP Kanamycin T7 Promoter His-MBP Transient
Type:
cDNA
Application:
Cloning
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Catalog No. ABIN4703841
Datasheet
Catalog No. ABIN4703841
Type:
cDNA
Application:
Cloning
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
Species:
Human
Synonyms:
HLA-DRB5
Insert length:
801 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Sequencing Primer:
  • MBP Forward primer: 5'-CGCAGATGTCCGCTTTCTGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human HLA-DRB5 cDNA Clone in Mammalian Expression Vector (His tag)
cDNA PExp Mammalian Expression Vector pPM-C-His Kanamycin CMV Promoter His tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-His
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
His tag
Expression:
Stable, Transient
Catalog No. ABIN4437677
Datasheet
Catalog No. ABIN4437677
Type:
cDNA
Application:
Protein Expression
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
Species:
Human
Synonyms:
HLA-DRB5
Insert length:
801 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-His
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
His tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human HLA-DRB5 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
NCBI Accession:
NM_002125
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5288276
Datasheet
Catalog No. ABIN5288276
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
NCBI Accession:
NM_002125
Species:
Human
Synonyms:
HLA-DRB5
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with a set of 3 gRNAs (3 x 300 μL) covering different sequences of HLA-DRB5
Format:
Viral Particles
Storage:
-80 °C
Human HLA-DRB5 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
NCBI Accession:
NM_002125
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5172681
Datasheet
Catalog No. ABIN5172681
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5)
NCBI Accession:
NM_002125
Species:
Human
Synonyms:
HLA-DRB5
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with a set of 3 gRNAs (3 x 300 μL) covering different sequences of HLA-DRB5
Format:
Viral Particles
Storage:
-80 °C
  • Type
    • Plasmid
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
  • Application
    • Protein Expression (PExp)
    • Cloning (Clon)
    • Genome Editing with Engineered Nucleases (GEEN)
  • Conjugate
    • Un-conjugated
    • His tag
    • DYKDDDDK Tag
    • GFP tag
    • HA tag
    • His-GST
    • His-MBP
    • Myc-DYKDDDDK Tag
  • Vector Backbone
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-AC-GFP
    • pCMV6-Entry
    • pDONR223
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pcDNA3.1+C-(K)-DYK
  • Vector
    • Mammalian Expression Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Cloning Vector
    • Gateway Cloning Vector
  • Insert
    • ORF
    • cDNA
    • gRNA
    • gRNA + Cas9
  • Bacterial Resistance
    • Ampicillin
    • Kanamycin
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • CMV Promoter
    • U6 Promoter
    • T7 Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Liquid
    • Lyophilized
    • Viral Particles

Synonyms and alternative names related to HLA-DRB5

  • major histocompatibility complex, class II, DR beta 5 (HLA-DRB5)
  • HLA-DRB

Gene-IDs for different species

Protein level used designations for HLA-DRB5

  • DR beta-5
  • DR-9
  • DR2-beta-2
  • DR9
  • HLA class II histocompatibility antigen, DR beta 5 chain
  • HLA class II histocompatibility antigen, DR-5 beta chain
  • HLA class II histocompatibility antigen, DRB1-9 beta chain
  • MHC HLA-DR-beta cell surface glycoprotein
  • MHC HLA-DR-beta chain
  • MHC class II HLA beta chain
  • MHC class II antigen DRB1*9
  • MHC class II antigen DRB5
  • dw2
  • human leucocyte antigen DRB5
  • leukocyte antigen class II
Other products related to HLA-DRB5 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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