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HMGCL (3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase, HMGCL)

Short Description: The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
More information related to gene HMGCL.

Products related to HMGCL Gene:

54 results :

Human HMGCL cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4476608
Datasheet
Catalog No. ABIN4476608
Type:
cDNA
Application:
Protein Expression
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
Species:
Human
Synonyms:
hmgcl.S, HMGCL, AFUA_7G01720, NFIA_114450, ACLA_065820, AOR_1_910074, PMAA_004600, TSTA_103060, ARB_04874, TRV_06573, Hmgcl, hmgcl
Insert length:
978 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Rat HMGCL CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
NCBI Accession:
NM_024386
Species:
Rat
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5245455
Datasheet
Catalog No. ABIN5245455
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
NCBI Accession:
NM_024386
Species:
Rat
Synonyms:
hmgcl.S, HMGCL, AFUA_7G01720, NFIA_114450, ACLA_065820, AOR_1_910074, PMAA_004600, TSTA_103060, ARB_04874, TRV_06573, Hmgcl, hmgcl
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Hmgcl
Format:
Viral Particles
Storage:
-80 °C
Mouse HMGCL CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
NCBI Accession:
NM_008254
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5245453
Datasheet
Catalog No. ABIN5245453
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
NCBI Accession:
NM_008254
Species:
Mouse
Synonyms:
hmgcl.S, HMGCL, AFUA_7G01720, NFIA_114450, ACLA_065820, AOR_1_910074, PMAA_004600, TSTA_103060, ARB_04874, TRV_06573, Hmgcl, hmgcl
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Hmgcl
Format:
Viral Particles
Storage:
-80 °C
Human HMGCL CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
NCBI Accession:
NM_000191
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5245451
Datasheet
Catalog No. ABIN5245451
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
NCBI Accession:
NM_000191
Species:
Human
Synonyms:
hmgcl.S, HMGCL, AFUA_7G01720, NFIA_114450, ACLA_065820, AOR_1_910074, PMAA_004600, TSTA_103060, ARB_04874, TRV_06573, Hmgcl, hmgcl
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of HMGCL
Format:
Viral Particles
Storage:
-80 °C
Rat HMGCL CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
NCBI Accession:
NM_024386
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5130024
Datasheet
Catalog No. ABIN5130024
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
NCBI Accession:
NM_024386
Species:
Rat
Synonyms:
hmgcl.S, HMGCL, AFUA_7G01720, NFIA_114450, ACLA_065820, AOR_1_910074, PMAA_004600, TSTA_103060, ARB_04874, TRV_06573, Hmgcl, hmgcl
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Hmgcl
Format:
Viral Particles
Storage:
-80 °C
Mouse HMGCL CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
NCBI Accession:
NM_008254
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5130022
Datasheet
Catalog No. ABIN5130022
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
NCBI Accession:
NM_008254
Species:
Mouse
Synonyms:
hmgcl.S, HMGCL, AFUA_7G01720, NFIA_114450, ACLA_065820, AOR_1_910074, PMAA_004600, TSTA_103060, ARB_04874, TRV_06573, Hmgcl, hmgcl
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Hmgcl
Format:
Viral Particles
Storage:
-80 °C
Human HMGCL CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
NCBI Accession:
NM_000191
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5130020
Datasheet
Catalog No. ABIN5130020
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
NCBI Accession:
NM_000191
Species:
Human
Synonyms:
hmgcl.S, HMGCL, AFUA_7G01720, NFIA_114450, ACLA_065820, AOR_1_910074, PMAA_004600, TSTA_103060, ARB_04874, TRV_06573, Hmgcl, hmgcl
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of HMGCL
Format:
Viral Particles
Storage:
-80 °C
Human HMGCL cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4832998
Datasheet
Catalog No. ABIN4832998
Type:
cDNA
Application:
Cloning
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
Species:
Human
Synonyms:
hmgcl.S, HMGCL, AFUA_7G01720, NFIA_114450, ACLA_065820, AOR_1_910074, PMAA_004600, TSTA_103060, ARB_04874, TRV_06573, Hmgcl, hmgcl
Insert length:
978 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human HMGCL cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4762983
Datasheet
Catalog No. ABIN4762983
Type:
cDNA
Application:
Cloning
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
Species:
Human
Synonyms:
hmgcl.S, HMGCL, AFUA_7G01720, NFIA_114450, ACLA_065820, AOR_1_910074, PMAA_004600, TSTA_103060, ARB_04874, TRV_06573, Hmgcl, hmgcl
Insert length:
978 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human HMGCL cDNA Clone in Bacterial Expression Vector (His-MBP)
cDNA Clon Bacterial Expression Vector pPB-His-MBP Kanamycin T7 Promoter His-MBP Transient
Type:
cDNA
Application:
Cloning
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Catalog No. ABIN4703868
Datasheet
Catalog No. ABIN4703868
Type:
cDNA
Application:
Cloning
Gene:
3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL)
Species:
Human
Synonyms:
hmgcl.S, HMGCL, AFUA_7G01720, NFIA_114450, ACLA_065820, AOR_1_910074, PMAA_004600, TSTA_103060, ARB_04874, TRV_06573, Hmgcl, hmgcl
Insert length:
978 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Sequencing Primer:
  • MBP Forward primer: 5'-CGCAGATGTCCGCTTTCTGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
    • Rat
    • Mouse
  • Application
    • Protein Expression (PExp)
    • Genome Editing with Engineered Nucleases (GEEN)
    • RNA Interference (RNAi)
    • Cloning (Clon)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • His tag
    • Myc-DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • DYKDDDDK Tag
    • RFP tag
  • Vector Backbone
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-Entry
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pRS
    • pCMV6-AC-GFP
    • pCas-Guide
    • pcDNA3.1+C-(K)-DYK
    • pCMV6-AC
    • pCMV6-XL5
    • pDONR223
    • pRFP-C-RS
  • Vector
    • Mammalian Expression Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Gateway Cloning Vector
  • Insert
    • cDNA
    • shRNA
    • ORF
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Ampicillin
    • Kanamycin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to HMGCL

  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase S homeolog (hmgcl.S)
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (HMGCL)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (AFUA_7G01720)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (NFIA_114450)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (ACLA_065820)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (AOR_1_910074)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (PMAA_004600)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (TSTA_103060)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (ARB_04874)
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (TRV_06573)
  • 3-hydroxy-3-methylglutaryl-Coenzyme A lyase (Hmgcl)
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (Hmgcl)
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (hmgcl)
  • Afu7g01720
  • AO090038000541
  • AW476067
  • HL
  • zgc:56248

Gene-IDs for different species

Protein level used designations for HMGCL

  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)
  • 3-hydroxy-3-methylglutarate-CoA lyase
  • HL
  • HMG-CoA lyase
  • hydroxymethylglutaryl-CoA lyase, mitochondrial
  • 3-hydroxy-3-methylglutaryl-CoA lyase
  • hydroxymethylglutaricaciduria
  • mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase
  • 3-hydroxy-3-methylglutaryl-Coenzyme A lyase
Other products related to HMGCL such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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