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HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase, HMGCR)

Short Description: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
More information related to gene HMGCR.

Products related to HMGCR Gene:

57 results :

Human HMGCR cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4476610
Datasheet
Catalog No. ABIN4476610
Type:
cDNA
Application:
Protein Expression
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
Species:
Human
Synonyms:
HMGCR, hmgcr.L, Hmgcr, hmgcrb
Insert length:
2508 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Rat HMGCR CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
NCBI Accession:
NM_013134
Species:
Rat
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5259457
Datasheet
Catalog No. ABIN5259457
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
NCBI Accession:
NM_013134
Species:
Rat
Synonyms:
HMGCR, hmgcr.L, Hmgcr, hmgcrb
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Hmgcr
Format:
Viral Particles
Storage:
-80 °C
Mouse HMGCR CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
NCBI Accession:
NM_008255
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5259455
Datasheet
Catalog No. ABIN5259455
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
NCBI Accession:
NM_008255
Species:
Mouse
Synonyms:
HMGCR, hmgcr.L, Hmgcr, hmgcrb
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Hmgcr
Format:
Viral Particles
Storage:
-80 °C
Human HMGCR CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
NCBI Accession:
NM_001130996
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5259453
Datasheet
Catalog No. ABIN5259453
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
NCBI Accession:
NM_001130996
Species:
Human
Synonyms:
HMGCR, hmgcr.L, Hmgcr, hmgcrb
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of HMGCR
Format:
Viral Particles
Storage:
-80 °C
Rat HMGCR CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
NCBI Accession:
NM_013134
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5143950
Datasheet
Catalog No. ABIN5143950
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
NCBI Accession:
NM_013134
Species:
Rat
Synonyms:
HMGCR, hmgcr.L, Hmgcr, hmgcrb
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Hmgcr
Format:
Viral Particles
Storage:
-80 °C
Mouse HMGCR CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
NCBI Accession:
NM_008255
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5143948
Datasheet
Catalog No. ABIN5143948
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
NCBI Accession:
NM_008255
Species:
Mouse
Synonyms:
HMGCR, hmgcr.L, Hmgcr, hmgcrb
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Hmgcr
Format:
Viral Particles
Storage:
-80 °C
Human HMGCR CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
NCBI Accession:
NM_001130996
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5143946
Datasheet
Catalog No. ABIN5143946
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
NCBI Accession:
NM_001130996
Species:
Human
Synonyms:
HMGCR, hmgcr.L, Hmgcr, hmgcrb
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of HMGCR
Format:
Viral Particles
Storage:
-80 °C
Human HMGCR cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4833000
Datasheet
Catalog No. ABIN4833000
Type:
cDNA
Application:
Cloning
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
Species:
Human
Synonyms:
HMGCR, hmgcr.L, Hmgcr, hmgcrb
Insert length:
2508 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human HMGCR cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4762985
Datasheet
Catalog No. ABIN4762985
Type:
cDNA
Application:
Cloning
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
Species:
Human
Synonyms:
HMGCR, hmgcr.L, Hmgcr, hmgcrb
Insert length:
2508 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human HMGCR cDNA Clone in Bacterial Expression Vector (His-MBP)
cDNA Clon Bacterial Expression Vector pPB-His-MBP Kanamycin T7 Promoter His-MBP Transient
Type:
cDNA
Application:
Cloning
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Catalog No. ABIN4703870
Datasheet
Catalog No. ABIN4703870
Type:
cDNA
Application:
Cloning
Gene:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
Species:
Human
Synonyms:
HMGCR, hmgcr.L, Hmgcr, hmgcrb
Insert length:
2508 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Sequencing Primer:
  • MBP Forward primer: 5'-CGCAGATGTCCGCTTTCTGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • OriGene
    • antibodies-online
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
    • Mouse
    • Rat
  • Application
    • Protein Expression (PExp)
    • Genome Editing with Engineered Nucleases (GEEN)
    • RNA Interference (RNAi)
    • Cloning (Clon)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • Myc-DYKDDDDK Tag
    • His tag
    • HA tag
    • His-GST
    • His-MBP
    • DYKDDDDK Tag
    • RFP tag
  • Vector Backbone
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-Entry
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pRS
    • pCMV6-AC-GFP
    • pCMV6-XL5
    • pCas-Guide
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pRFP-C-RS
    • pcDNA3.1+C-(K)-DYK
    • pDONR223
  • Vector
    • Lentiviral Vector
    • Mammalian Expression Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Gateway Cloning Vector
  • Insert
    • cDNA
    • ORF
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Ampicillin
    • Kanamycin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • T7 Promoter
    • PGK Promoter
    • SFFV Promoter
    • Enhanced CMV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to HMGCR

  • 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)
  • 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog (hmgcr.L)
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr)
  • 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr)
  • HMG Coenzyme A reductase (Hmgcr)
  • 3-hydroxy-3-methylglutaryl-CoA reductase b (hmgcrb)
  • 3H3M
  • BcDNA:LD15354
  • bro1
  • bs32f05.y1
  • CG10367
  • Clb
  • clb
  • Dmel\\CG10367
  • DmHMG-CoAr
  • Hmg
  • hmg-coa-r
  • HMG-CoAR
  • HmG-CoAR
  • hmgc
  • HMGCoAR
  • HMGCoAr
  • HMGCoARr
  • HMGCR
  • hmgcr
  • hmgcr2
  • HMGCR_Dm
  • HMGR
  • hmgrc
  • im:6912716
  • l(3)01152
  • l(3)04684
  • LDLCQ3
  • Red
  • zgc:110746

Gene-IDs for different species

Protein level used designations for HMGCR

  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
  • 3-hydroxy-3-methylglutaryl coenzyme A reductase/HMG-CoA reductase
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase
  • 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
  • HMG-CoA reductase
  • hydroxymethylglutaryl-CoA reductase
  • 3-hydroxy-3-methylglutaryl CoA reductase
  • 3-hydroxy-3-methylglutaryl-CoA reductase
  • 3-Hydroxy-3-Methylglutaryl CoA reductase
  • 3-hydroxy-3-methylglutaryl coenzyme A reductase
  • CG10367-PA
  • HMG coenzyme A reductase
  • HMGCo-A reductase
  • HMGCoA reductase
  • Hmg-CoA-reductase
  • Hmgcr-PA
  • columbus
  • lethal (3) 04684
  • 3-alpha-hydroxy-3-methylglutaryl-CoA reductase
  • 3-hydroxy-3-methylglutaryl-CoA reductase b
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b
  • hmgcr1b
  • hmgrb
Other products related to HMGCR such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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