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MLL1 (Myeloid/lymphoid Or Mixed-Lineage Leukemia 1, MLL1)

Short Description: Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis (By similarity).
More information related to gene MLL1.

Products related to MLL1 Gene:

16 results :

Mouse MLL1 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5283229
Datasheet
Catalog No. ABIN5283229
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Synonyms:
Kmt2a
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Mll1
Format:
Viral Particles
Storage:
-80 °C
Mouse MLL1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5167642
Datasheet
Catalog No. ABIN5167642
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Synonyms:
Kmt2a
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Mll1
Format:
Viral Particles
Storage:
-80 °C
Mouse MLL1 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5283228
Datasheet
Catalog No. ABIN5283228
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Synonyms:
Kmt2a
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with a set of 3 gRNAs (3 x 300 μL) covering different sequences of Mll1
Format:
Viral Particles
Storage:
-80 °C
Mouse MLL1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5167641
Datasheet
Catalog No. ABIN5167641
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Synonyms:
Kmt2a
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with a set of 3 gRNAs (3 x 300 μL) covering different sequences of Mll1
Format:
Viral Particles
Storage:
-80 °C
Mouse MLL1 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5765449
Datasheet
Catalog No. ABIN5765449
Type:
ORF
Application:
Cloning
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Synonyms:
Kmt2a
Insert length:
11892 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Mouse MLL1 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4449013
Datasheet
Catalog No. ABIN4449013
Type:
cDNA
Application:
Protein Expression
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Synonyms:
Kmt2a
Insert length:
11892 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Mouse MLL1 cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4857810
Datasheet
Catalog No. ABIN4857810
Type:
cDNA
Application:
Cloning
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Synonyms:
Kmt2a
Insert length:
16439 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Mouse MLL1 cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4648330
Datasheet
Catalog No. ABIN4648330
Type:
cDNA
Application:
Cloning
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Synonyms:
Kmt2a
Insert length:
11892 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Mouse MLL1 cDNA Clone in Bacterial Expression Vector (His-MBP)
cDNA Clon Bacterial Expression Vector pPB-His-MBP Kanamycin T7 Promoter His-MBP Transient
Type:
cDNA
Application:
Cloning
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Catalog No. ABIN4728679
Datasheet
Catalog No. ABIN4728679
Type:
cDNA
Application:
Cloning
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Synonyms:
Kmt2a
Insert length:
16439 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Sequencing Primer:
  • MBP Forward primer: 5'-CGCAGATGTCCGCTTTCTGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Mouse MLL1 cDNA Clone in Mammalian Expression Vector (His tag)
cDNA PExp Mammalian Expression Vector pPM-C-His Kanamycin CMV Promoter His tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-His
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
His tag
Expression:
Stable, Transient
Catalog No. ABIN4393706
Datasheet
Catalog No. ABIN4393706
Type:
cDNA
Application:
Protein Expression
Gene:
Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1)
NCBI Accession:
NM_001081049
Species:
Mouse
Synonyms:
Kmt2a
Insert length:
11892 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-His
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
His tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
  • Reactivity
    • Mouse
    • Rat
  • Application
    • RNA Interference (RNAi)
    • Protein Expression (PExp)
    • Cloning (Clon)
    • Genome Editing with Engineered Nucleases (GEEN)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • His tag
    • HA tag
    • His-GST
    • His-MBP
    • RFP tag
  • Vector Backbone
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pRFP-C-RS
    • pRS
  • Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Mammalian Expression Vector
    • Cloning Vector
  • Insert
    • cDNA
    • shRNA
    • gRNA
    • gRNA + Cas9
    • ORF
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Puromycin
    • Neomycin
  • Promoter
    • U6 Promoter
    • T7 Promoter
    • CMV Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Liquid
    • Lyophilized
    • Viral Particles

Synonyms and alternative names related to MLL1

  • lysine methyltransferase 2A (Kmt2a)
  • lysine (K)-specific methyltransferase 2A (Kmt2a)
  • 6430520K01
  • ALL-1
  • All1
  • Cxxc7
  • HRX
  • HTRX1
  • mKIAA4050
  • Mll
  • Mll1

Gene-IDs for different species

Protein level used designations for MLL1

  • Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)
  • histone-lysine N-methyltransferase MLL
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
  • myeloid/lymphoid or mixed-lineage leukemia 1
  • histone-lysine N-methyltransferase 2A
  • lysine N-methyltransferase 2A
  • myeloid/lymphoid or mixed-lineage leukemia protein 1
  • trithorax Drosophila
  • zinc finger protein HRX
Other products related to MLL1 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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