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NPC1 (Niemann-Pick Disease, Type C1, NPC1)

Short Description: This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009].
More information related to gene NPC1.

Products related to NPC1 Gene:

48 results :

Human NPC1 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_000271
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5741820
Datasheet
Catalog No. ABIN5741820
Type:
ORF
Application:
Cloning
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_000271
Species:
Human
Synonyms:
NPC1, Npc1l1, Npc1, npc1, LOC579887
Insert length:
3837 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human NPC1 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_000271
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4489281
Datasheet
Catalog No. ABIN4489281
Type:
cDNA
Application:
Protein Expression
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_000271
Species:
Human
Synonyms:
NPC1, Npc1l1, Npc1, npc1, LOC579887
Insert length:
3837 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Rat NPC1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_153624
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5121234
Datasheet
Catalog No. ABIN5121234
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_153624
Species:
Rat
Synonyms:
NPC1, Npc1l1, Npc1, npc1, LOC579887
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Cdig2
Format:
Viral Particles
Storage:
-80 °C
Mouse NPC1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_008720
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5121232
Datasheet
Catalog No. ABIN5121232
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_008720
Species:
Mouse
Synonyms:
NPC1, Npc1l1, Npc1, npc1, LOC579887
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Npc1
Format:
Viral Particles
Storage:
-80 °C
Human NPC1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_000271
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5121230
Datasheet
Catalog No. ABIN5121230
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_000271
Species:
Human
Synonyms:
NPC1, Npc1l1, Npc1, npc1, LOC579887
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of NPC1
Format:
Viral Particles
Storage:
-80 °C
Mouse NPC1 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_008720
Species:
Mouse
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5741821
Datasheet
Catalog No. ABIN5741821
Type:
ORF
Application:
Cloning
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_008720
Species:
Mouse
Synonyms:
NPC1, Npc1l1, Npc1, npc1, LOC579887
Insert length:
3834 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human NPC1 cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_000271
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4836300
Datasheet
Catalog No. ABIN4836300
Type:
cDNA
Application:
Cloning
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_000271
Species:
Human
Synonyms:
NPC1, Npc1l1, Npc1, npc1, LOC579887
Insert length:
3837 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human NPC1 cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_000271
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4632750
Datasheet
Catalog No. ABIN4632750
Type:
cDNA
Application:
Cloning
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_000271
Species:
Human
Synonyms:
NPC1, Npc1l1, Npc1, npc1, LOC579887
Insert length:
3837 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human NPC1 cDNA Clone in Mammalian Expression Vector (His tag)
cDNA PExp Mammalian Expression Vector pPM-C-His Kanamycin CMV Promoter His tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_000271
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-His
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
His tag
Expression:
Stable, Transient
Catalog No. ABIN4424191
Datasheet
Catalog No. ABIN4424191
Type:
cDNA
Application:
Protein Expression
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_000271
Species:
Human
Synonyms:
NPC1, Npc1l1, Npc1, npc1, LOC579887
Insert length:
3837 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-His
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
His tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human NPC1 cDNA Clone in Bacterial Expression Vector (His-MBP)
cDNA Clon Bacterial Expression Vector pPB-His-MBP Kanamycin T7 Promoter His-MBP Transient
Type:
cDNA
Application:
Cloning
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_000271
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Catalog No. ABIN4707170
Datasheet
Catalog No. ABIN4707170
Type:
cDNA
Application:
Cloning
Gene:
Niemann-Pick Disease, Type C1 (NPC1)
NCBI Accession:
NM_000271
Species:
Human
Synonyms:
NPC1, Npc1l1, Npc1, npc1, LOC579887
Insert length:
3837 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Sequencing Primer:
  • MBP Forward primer: 5'-CGCAGATGTCCGCTTTCTGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
  • Reactivity
    • Human
    • Mouse
    • Rat
  • Cited in publications
  • Application
    • Protein Expression (PExp)
    • Genome Editing with Engineered Nucleases (GEEN)
    • Cloning (Clon)
    • RNA Interference (RNAi)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • His tag
    • Myc-DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • DYKDDDDK Tag
  • Vector Backbone
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-Entry
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pCas-Guide
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pORF
    • pRS
    • pCMV6-AC-GFP
    • pCMV6-XL4
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pcDNA3.1+C-(K)-DYK
  • Vector
    • Lentiviral Vector
    • Mammalian Expression Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
  • Insert
    • cDNA
    • ORF
    • gRNA + Cas9
    • gRNA
    • shRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • T7 Promoter
    • PGK Promoter
    • SFFV Promoter
    • Enhanced CMV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to NPC1

  • NPC intracellular cholesterol transporter 1 (NPC1)
  • NPC1 like intracellular cholesterol transporter 1 (Npc1l1)
  • NPC intracellular cholesterol transporter 1 (Npc1)
  • Niemann-Pick disease, type C1 (npc1)
  • Niemann-Pick C1 protein (LOC579887)
  • 9130221N23Rik
  • A430089E03Rik
  • C85354
  • Cdig2
  • D18Ertd139e
  • D18Ertd723e
  • Gm243
  • im:7149020
  • lcsd
  • nmf164
  • NPC
  • spm
  • wu:fb53a12
  • wu:fc29a12

Gene-IDs for different species

Protein level used designations for NPC1

  • Niemann-Pick C1 protein
  • Niemann-Pick C1-like protein 1
  • Niemann-Pick disease, type C1
  • Niemann-Pick disease, type C1-like 1
  • Niemann-Pick type C1 disease protein
  • Nasopharyngeal carcinoma 1
  • Niemann-Pick C1
  • sphingomyelinosis
  • Niemann-Pick C disease protein
  • Niemann Pick type C1
Other products related to NPC1 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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