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NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1, NPC1L1)

Short Description: The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
More information related to gene NPC1L1.

Products related to NPC1L1 Gene:

60 results :

Human NPC1L1 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5756279
Datasheet
Catalog No. ABIN5756279
Type:
ORF
Application:
Cloning
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
Species:
Human
Synonyms:
NPC1L1, npc1l1, Npc1l1
Insert length:
3999 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Rat NPC1L1 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
NCBI Accession:
NM_001002025
Species:
Rat
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5265111
Datasheet
Catalog No. ABIN5265111
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
NCBI Accession:
NM_001002025
Species:
Rat
Synonyms:
NPC1L1, npc1l1, Npc1l1
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Npc1l1
Format:
Viral Particles
Storage:
-80 °C
Mouse NPC1L1 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
NCBI Accession:
NM_207242
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5265109
Datasheet
Catalog No. ABIN5265109
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
NCBI Accession:
NM_207242
Species:
Mouse
Synonyms:
NPC1L1, npc1l1, Npc1l1
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Npc1l1
Format:
Viral Particles
Storage:
-80 °C
Human NPC1L1 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
NCBI Accession:
NM_013389
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5265107
Datasheet
Catalog No. ABIN5265107
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
NCBI Accession:
NM_013389
Species:
Human
Synonyms:
NPC1L1, npc1l1, Npc1l1
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of NPC1L1
Format:
Viral Particles
Storage:
-80 °C
Human NPC1L1 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4485471
Datasheet
Catalog No. ABIN4485471
Type:
cDNA
Application:
Protein Expression
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
Species:
Human
Synonyms:
NPC1L1, npc1l1, Npc1l1
Insert length:
3999 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Rat NPC1L1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
NCBI Accession:
NM_001002025
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5149559
Datasheet
Catalog No. ABIN5149559
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
NCBI Accession:
NM_001002025
Species:
Rat
Synonyms:
NPC1L1, npc1l1, Npc1l1
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Npc1l1
Format:
Viral Particles
Storage:
-80 °C
Mouse NPC1L1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
NCBI Accession:
NM_207242
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5149557
Datasheet
Catalog No. ABIN5149557
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
NCBI Accession:
NM_207242
Species:
Mouse
Synonyms:
NPC1L1, npc1l1, Npc1l1
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Npc1l1
Format:
Viral Particles
Storage:
-80 °C
Human NPC1L1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
NCBI Accession:
NM_013389
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5149555
Datasheet
Catalog No. ABIN5149555
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
NCBI Accession:
NM_013389
Species:
Human
Synonyms:
NPC1L1, npc1l1, Npc1l1
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of NPC1L1
Format:
Viral Particles
Storage:
-80 °C
Rat NPC1L1 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
NCBI Accession:
NM_001002025
Species:
Rat
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5756281
Datasheet
Catalog No. ABIN5756281
Type:
ORF
Application:
Cloning
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
NCBI Accession:
NM_001002025
Species:
Rat
Synonyms:
NPC1L1, npc1l1, Npc1l1
Insert length:
3996 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human NPC1L1 cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4836301
Datasheet
Catalog No. ABIN4836301
Type:
cDNA
Application:
Cloning
Gene:
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1)
Species:
Human
Synonyms:
NPC1L1, npc1l1, Npc1l1
Insert length:
3999 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
    • Mouse
    • Rat
  • Application
    • Protein Expression (PExp)
    • RNA Interference (RNAi)
    • Genome Editing with Engineered Nucleases (GEEN)
    • Cloning (Clon)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • His tag
    • Myc-DYKDDDDK Tag
    • DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • RFP tag
  • Vector Backbone
    • pCMV6-Entry
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pRS
    • pcDNA3.1+C-(K)-DYK
    • pCMV6-AC-GFP
    • pCMV6-XL5
    • pCas-Guide
    • pRFP-C-RS
    • pDONR223
  • Vector
    • Mammalian Expression Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
    • Gateway Cloning Vector
  • Insert
    • cDNA
    • ORF
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Ampicillin
    • Kanamycin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to NPC1L1

  • NPC1 like intracellular cholesterol transporter 1 (NPC1L1)
  • NPC1 like 1 (npc1l1)
  • NPC1-like 1 (npc1l1)
  • NPC1 like intracellular cholesterol transporter 1 (Npc1l1)
  • 9130221N23Rik
  • Gm243
  • NPC1L1
  • NPC11L1

Gene-IDs for different species

Protein level used designations for NPC1L1

  • NPC1-like 1
  • NPC1 (Niemann-Pick disease, type C1, gene)-like 1
  • Niemann-Pick C1-like protein 1
  • Niemann-Pick C1-like 1 protein
  • Niemann-Pick C1-like protein 1-like
  • Niemann-Pick disease, type C1
  • Niemann-Pick disease, type C1-like 1
Other products related to NPC1L1 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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