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RANKL (Tumor Necrosis Factor (Ligand) Superfamily, Member 11, TNFSF11)

Short Description: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008].
More information related to gene RANKL.

Products related to RANKL Gene:

66 results :

Human TNFSF11 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5721810
Datasheet
Catalog No. ABIN5721810
Type:
ORF
Application:
Cloning
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
Species:
Human
Synonyms:
TNFSF11, Tnfsf11, TNFRSF11B, tnfsf11.L
Insert length:
954 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human TNFSF11 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4486352
Datasheet
Catalog No. ABIN4486352
Type:
cDNA
Application:
Protein Expression
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
Species:
Human
Synonyms:
TNFSF11, Tnfsf11, TNFRSF11B, tnfsf11.L
Insert length:
954 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human TNFSF11 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
NCBI Accession:
NM_033012
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5085180
Datasheet
Catalog No. ABIN5085180
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
NCBI Accession:
NM_033012
Species:
Human
Synonyms:
TNFSF11, Tnfsf11, TNFRSF11B, tnfsf11.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of TNFSF11
Format:
Viral Particles
Storage:
-80 °C
Rat TNFSF11 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
NCBI Accession:
NM_057149
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5085184
Datasheet
Catalog No. ABIN5085184
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
NCBI Accession:
NM_057149
Species:
Rat
Synonyms:
TNFSF11, Tnfsf11, TNFRSF11B, tnfsf11.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Tnfsf11
Format:
Viral Particles
Storage:
-80 °C
Mouse TNFSF11 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
NCBI Accession:
NM_011613
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5085182
Datasheet
Catalog No. ABIN5085182
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
NCBI Accession:
NM_011613
Species:
Mouse
Synonyms:
TNFSF11, Tnfsf11, TNFRSF11B, tnfsf11.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Tnfsf11
Format:
Viral Particles
Storage:
-80 °C
Human TNFSF11 cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4842134
Datasheet
Catalog No. ABIN4842134
Type:
cDNA
Application:
Cloning
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
Species:
Human
Synonyms:
TNFSF11, Tnfsf11, TNFRSF11B, tnfsf11.L
Insert length:
954 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human TNFSF11 cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4629823
Datasheet
Catalog No. ABIN4629823
Type:
cDNA
Application:
Cloning
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
Species:
Human
Synonyms:
TNFSF11, Tnfsf11, TNFRSF11B, tnfsf11.L
Insert length:
954 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human TNFSF11 cDNA Clone in Bacterial Expression Vector (His-MBP)
cDNA Clon Bacterial Expression Vector pPB-His-MBP Kanamycin T7 Promoter His-MBP Transient
Type:
cDNA
Application:
Cloning
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Catalog No. ABIN4713003
Datasheet
Catalog No. ABIN4713003
Type:
cDNA
Application:
Cloning
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
Species:
Human
Synonyms:
TNFSF11, Tnfsf11, TNFRSF11B, tnfsf11.L
Insert length:
954 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Sequencing Primer:
  • MBP Forward primer: 5'-CGCAGATGTCCGCTTTCTGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human TNFSF11 cDNA Clone in Mammalian Expression Vector (His tag)
cDNA PExp Mammalian Expression Vector pPM-C-His Kanamycin CMV Promoter His tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-His
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
His tag
Expression:
Stable, Transient
Catalog No. ABIN4421266
Datasheet
Catalog No. ABIN4421266
Type:
cDNA
Application:
Protein Expression
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
Species:
Human
Synonyms:
TNFSF11, Tnfsf11, TNFRSF11B, tnfsf11.L
Insert length:
954 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-His
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
His tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Mouse TNFSF11 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
NCBI Accession:
NM_011613
Species:
Mouse
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5721811
Datasheet
Catalog No. ABIN5721811
Type:
ORF
Application:
Cloning
Gene:
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)
NCBI Accession:
NM_011613
Species:
Mouse
Synonyms:
TNFSF11, Tnfsf11, TNFRSF11B, tnfsf11.L
Insert length:
951 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • OriGene
    • antibodies-online
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
    • Mouse
    • Rat
  • Cited in publications
  • Application
    • Protein Expression (PExp)
    • RNA Interference (RNAi)
    • Genome Editing with Engineered Nucleases (GEEN)
    • Cloning (Clon)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • Myc-DYKDDDDK Tag
    • His tag
    • HA tag
    • His-GST
    • His-MBP
    • DYKDDDDK Tag
    • RFP tag
  • Vector Backbone
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-Entry
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pRS
    • pCMV6-AC-GFP
    • pCas-Guide
    • pRFP-C-RS
    • pcDNA3.1+C-(K)-DYK
    • pCMV6-XL4
    • pCMV6-XL5
    • pDONR223
  • Vector
    • Lentiviral Vector
    • Mammalian Expression Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
    • Gateway Cloning Vector
  • Insert
    • ORF
    • cDNA
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Ampicillin
    • Kanamycin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to RANKL

  • TNF superfamily member 11 (TNFSF11)
  • tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11)
  • TNF superfamily member 11 (Tnfsf11)
  • TNF receptor superfamily member 11b (TNFRSF11B)
  • TNF superfamily member 11 L homeolog (tnfsf11.L)
  • CD254
  • cd254
  • hRANKL2
  • Ly109l
  • ODF
  • odf
  • OPG
  • OPGL
  • opgl
  • OPTB2
  • optb2
  • RANKL
  • rankl
  • sOdf
  • sodf
  • TNFSF11
  • tnfsf11
  • TRANCE
  • Trance
  • trance

Gene-IDs for different species

Protein level used designations for RANKL

  • TNF-related activation-induced cytokine
  • osteoclast differentiation factor
  • osteoprotegerin ligand
  • receptor activator of nuclear factor kappa B ligand
  • receptor activator of nuclear factor kappa-B ligand
  • tumor necrosis factor ligand superfamily member 11
  • tumor necrosis factor (ligand) superfamily, member 11
  • Receptor activator of nuclear factor kappa-B ligand
  • OPG ligand
  • receptor activator of NF-kappaB ligand
  • tumor necrosis factor-related activation-induced cytokine
  • ODF
  • OPGL
  • TRANCE
  • osteoprotegerin
  • TNF superfamily member 11 L homeolog
  • tumor necrosis factor superfamily member 11 L homeolog
Other products related to RANKL such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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