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RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase, RFWD2)

Short Description: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1 (By similarity).
More information related to gene RFWD2.

Products related to RFWD2 Gene:

57 results :

Human RFWD2 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_022457
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5764085
Datasheet
Catalog No. ABIN5764085
Type:
ORF
Application:
Cloning
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_022457
Species:
Human
Synonyms:
RFWD2, Rfwd2, rfwd2, rfwd2.L
Insert length:
2196 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Rat RFWD2 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_001025126
Species:
Rat
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5280231
Datasheet
Catalog No. ABIN5280231
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_001025126
Species:
Rat
Synonyms:
RFWD2, Rfwd2, rfwd2, rfwd2.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Rfwd2
Format:
Viral Particles
Storage:
-80 °C
Mouse RFWD2 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_011931
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5280229
Datasheet
Catalog No. ABIN5280229
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_011931
Species:
Mouse
Synonyms:
RFWD2, Rfwd2, rfwd2, rfwd2.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Rfwd2
Format:
Viral Particles
Storage:
-80 °C
Human RFWD2 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_001001740
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5280227
Datasheet
Catalog No. ABIN5280227
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_001001740
Species:
Human
Synonyms:
RFWD2, Rfwd2, rfwd2, rfwd2.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of RFWD2
Format:
Viral Particles
Storage:
-80 °C
Rat RFWD2 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_001025126
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5164644
Datasheet
Catalog No. ABIN5164644
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_001025126
Species:
Rat
Synonyms:
RFWD2, Rfwd2, rfwd2, rfwd2.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Rfwd2
Format:
Viral Particles
Storage:
-80 °C
Human RFWD2 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_001001740
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5164640
Datasheet
Catalog No. ABIN5164640
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_001001740
Species:
Human
Synonyms:
RFWD2, Rfwd2, rfwd2, rfwd2.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of RFWD2
Format:
Viral Particles
Storage:
-80 °C
Mouse RFWD2 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_011931
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5164642
Datasheet
Catalog No. ABIN5164642
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_011931
Species:
Mouse
Synonyms:
RFWD2, Rfwd2, rfwd2, rfwd2.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Rfwd2
Format:
Viral Particles
Storage:
-80 °C
Mouse RFWD2 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_011931
Species:
Mouse
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5764086
Datasheet
Catalog No. ABIN5764086
Type:
ORF
Application:
Cloning
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_011931
Species:
Mouse
Synonyms:
RFWD2, Rfwd2, rfwd2, rfwd2.L
Insert length:
2202 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Rat RFWD2 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_001025126
Species:
Rat
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5764087
Datasheet
Catalog No. ABIN5764087
Type:
ORF
Application:
Cloning
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_001025126
Species:
Rat
Synonyms:
RFWD2, Rfwd2, rfwd2, rfwd2.L
Insert length:
1302 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Rat RFWD2 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_001025126
Species:
Rat
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4466295
Datasheet
Catalog No. ABIN4466295
Type:
cDNA
Application:
Protein Expression
Gene:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2)
NCBI Accession:
NM_001025126
Species:
Rat
Synonyms:
RFWD2, Rfwd2, rfwd2, rfwd2.L
Insert length:
1302 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
  • Reactivity
    • Human
    • Rat
    • Mouse
  • Application
    • Protein Expression (PExp)
    • Genome Editing with Engineered Nucleases (GEEN)
    • RNA Interference (RNAi)
    • Cloning (Clon)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • His tag
    • Myc-DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • DYKDDDDK Tag
    • RFP tag
  • Vector Backbone
    • pCMV6-Entry
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pRS
    • pCMV6-AC-GFP
    • pCas-Guide
    • pCMV6-XL6
    • pRFP-C-RS
    • pcDNA3.1+C-(K)-DYK
  • Vector
    • Mammalian Expression Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
  • Insert
    • cDNA
    • ORF
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
    • SP6 Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to RFWD2

  • ring finger and WD repeat domain 2 (RFWD2)
  • ring finger and WD repeat domain 2 (Rfwd2)
  • ring finger and WD repeat domain 2, E3 ubiquitin protein ligase (rfwd2)
  • ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog (rfwd2.L)
  • ring finger and WD repeat domain 2 (rfwd2)
  • AI316802
  • C80879
  • COP1
  • Cop1
  • cop1
  • RFWD2
  • RGD1304773
  • RNF200
  • rnf200
  • zgc:163067

Gene-IDs for different species

Protein level used designations for RFWD2

  • E3 ubiquitin-protein ligase RFWD2
  • RING finger and WD repeat domain protein 2
  • RING finger protein 200
  • constitutive photomorphogenesis protein 1 homolog
  • constitutive photomorphogenic protein (COP1)
  • hCOP1
  • putative ubiquitin ligase COP1
  • constitutive photomorphogenic protein 1
  • mCOP1
  • ring finger and WD repeat domain 2
  • rp11-318c24.3
Other products related to RFWD2 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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