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RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1, RIPK1)

Short Description: Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.
More information related to gene RIPK1.

Products related to RIPK1 Gene:

70 results :

Human RIPK1 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5757388
Datasheet
Catalog No. ABIN5757388
Type:
ORF
Application:
Cloning
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
Species:
Human
Synonyms:
RIPK1, Ripk1, ripk1.L
Insert length:
321 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human RIPK1 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_003804
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5757389
Datasheet
Catalog No. ABIN5757389
Type:
ORF
Application:
Cloning
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_003804
Species:
Human
Synonyms:
RIPK1, Ripk1, ripk1.L
Insert length:
2016 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human RIPK1 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4480414
Datasheet
Catalog No. ABIN4480414
Type:
cDNA
Application:
Protein Expression
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
Species:
Human
Synonyms:
RIPK1, Ripk1, ripk1.L
Insert length:
321 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human RIPK1 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_003804
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4490090
Datasheet
Catalog No. ABIN4490090
Type:
cDNA
Application:
Protein Expression
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_003804
Species:
Human
Synonyms:
RIPK1, Ripk1, ripk1.L
Insert length:
2016 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Rat RIPK1 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_001107350
Species:
Rat
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5267161
Datasheet
Catalog No. ABIN5267161
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_001107350
Species:
Rat
Synonyms:
RIPK1, Ripk1, ripk1.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Ripk1
Format:
Viral Particles
Storage:
-80 °C
Mouse RIPK1 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_009068
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5267159
Datasheet
Catalog No. ABIN5267159
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_009068
Species:
Mouse
Synonyms:
RIPK1, Ripk1, ripk1.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Ripk1
Format:
Viral Particles
Storage:
-80 °C
Human RIPK1 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_003804
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5267157
Datasheet
Catalog No. ABIN5267157
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_003804
Species:
Human
Synonyms:
RIPK1, Ripk1, ripk1.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of RIPK1
Format:
Viral Particles
Storage:
-80 °C
Mouse RIPK1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_009068
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5151599
Datasheet
Catalog No. ABIN5151599
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_009068
Species:
Mouse
Synonyms:
RIPK1, Ripk1, ripk1.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Ripk1
Format:
Viral Particles
Storage:
-80 °C
Rat RIPK1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_001107350
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5151601
Datasheet
Catalog No. ABIN5151601
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_001107350
Species:
Rat
Synonyms:
RIPK1, Ripk1, ripk1.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Ripk1
Format:
Viral Particles
Storage:
-80 °C
Human RIPK1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_003804
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5151597
Datasheet
Catalog No. ABIN5151597
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1)
NCBI Accession:
NM_003804
Species:
Human
Synonyms:
RIPK1, Ripk1, ripk1.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of RIPK1
Format:
Viral Particles
Storage:
-80 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
    • Mouse
    • Rat
  • Cited in publications
  • Application
    • Protein Expression (PExp)
    • Genome Editing with Engineered Nucleases (GEEN)
    • Cloning (Clon)
    • RNA Interference (RNAi)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • His tag
    • Myc-DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • RFP tag
    • DYKDDDDK Tag
  • Vector Backbone
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-Entry
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pORF
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pPB-His-GST
    • pPB-His-MBP
    • pRFP-C-RS
    • pRS
    • pCMV6-XL5
    • pCas-Guide
    • pCMV6-AC-GFP
    • pDONR223
    • pcDNA3.1+C-(K)-DYK
  • Vector
    • Lentiviral Vector
    • Mammalian Expression Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
    • Gateway Cloning Vector
  • Insert
    • cDNA
    • ORF
    • shRNA
    • gRNA
    • gRNA + Cas9
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • T7 Promoter
    • PGK Promoter
    • Enhanced CMV Promoter
    • SFFV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to RIPK1

  • receptor interacting serine/threonine kinase 1 (RIPK1)
  • receptor (TNFRSF)-interacting serine-threonine kinase 1 (Ripk1)
  • receptor interacting serine/threonine kinase 1 (Ripk1)
  • receptor interacting serine/threonine kinase 1 L homeolog (ripk1.L)
  • D330015H01Rik
  • Rinp
  • RIP
  • RIP1
  • Rip1
  • rip1
  • ripk1
  • xrip1
  • xRIP1beta

Gene-IDs for different species

Protein level used designations for RIPK1

  • RIP-1
  • cell death protein RIP
  • receptor interacting protein
  • receptor-interacting protein 1
  • receptor-interacting serine/threonine-protein kinase 1
  • serine/threonine-protein kinase RIP
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • receptor interacting serine/threonine kinase 1 L homeolog
  • receptor-interacting protein 1 beta
Other products related to RIPK1 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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