ROBO3 (Roundabout, Axon Guidance Receptor, Homolog 3, ROBO3)
Short Description: This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS)\; an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated. [provided by RefSeq, Dec 2009].
More information related to gene ROBO3.
More information related to gene ROBO3.
Products related to ROBO3 Gene:
Recommended next Filters:
54 results :
ORF
Clon
Cloning Vector
pORF
Spectinomycin
unconjugated
Transient
- Type:
- ORF
- Application:
- Cloning
- Gene:
- Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3)
- Species:
- Human
- Vector type:
- Cloning Vector
- Vector backbone:
- pORF
- Resistance Gene:
- Spectinomycin
- Expression:
- Transient
cDNA
PExp
Bacterial Expression Vector
pPB-His-MBP
Kanamycin
T7 Promoter
His-MBP
Transient
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-His-MBP
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His-MBP
- Expression:
- Transient
cDNA
PExp
Bacterial Expression Vector
pPB-His-GST
Kanamycin
T7 Promoter
His-GST
Transient
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-His-GST
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His-GST
- Expression:
- Transient
cDNA
PExp
Mammalian Expression Vector
pPM-C-HA
Kanamycin
CMV Promoter
HA tag
Stable
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pPM-C-HA
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- HA tag
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3)
- NCBI Accession:
- NM_001164767
- Species:
- Mouse
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3)
- NCBI Accession:
- NM_001108135
- Species:
- Rat
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3)
- NCBI Accession:
- NM_022370
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
cDNA
Clon
Bacterial Expression Vector
pPB-His-GST
Kanamycin
T7 Promoter
His-GST
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-His-GST
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His-GST
- Expression:
- Transient
cDNA
Clon
Bacterial Expression Vector
pPB-N-His
Kanamycin
T7 Promoter
His tag
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-N-His
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His tag
- Expression:
- Transient
cDNA
Clon
Bacterial Expression Vector
pPB-His-MBP
Kanamycin
T7 Promoter
His-MBP
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-His-MBP
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His-MBP
- Expression:
- Transient
Synonyms and alternative names related to ROBO3
- roundabout guidance receptor 3 (ROBO3)
- roundabout 3 (robo3)
- roundabout guidance receptor 3 (Robo3)
- robo3 (LOC658818)
- roundabout guidance receptor 3 L homeolog (robo3.L)
- roundabout, axon guidance receptor, homolog 3 (Drosophila) (robo3)
- cb503
- CG5423
- CG14345
- CT17158
- DKFZp468G0223
- DmelCG5423
- dRobo-3
- HGPPS
- HGPS
- RBIG1
- Rbig1
- Rig-1
- RIG1
- Rig1
- Robo-3
- Robo3
- ROBO3
- robo3
- Robo3a
- Robo3b
Gene-IDs for different species
Protein level used designations for ROBO3
- retinoblastoma inhibiting gene 1
- roundabout homolog 3
- roundabout-like protein 3
- robo3
- CG5423-PA
- robo3-PA
- roundabout, axon guidance receptor, homolog 3
- roundabout, axon guidance receptor, homolog 3 (Drosophila)
- GLEAN_06743
- roundabout 3
- roundabout homolog 3-like
- retinoblastoma-inhibiting gene 1 protein
- roundabout (axon guidance receptor, Drosophila) homolog 3
- twi
- twitch twice
Proteomics products related to ROBO3 Gene
Other products related to ROBO3 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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