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SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1, SHC1)

Short Description: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
More information related to gene SHC1.

Products related to SHC1 Gene:

87 results :

Human SHC1 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5734737
Datasheet
Catalog No. ABIN5734737
Type:
ORF
Application:
Cloning
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
Species:
Human
Synonyms:
SHC1, shc1, Shc1, shc1.L
Insert length:
1425 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human SHC1 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4481082
Datasheet
Catalog No. ABIN4481082
Type:
cDNA
Application:
Protein Expression
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
Species:
Human
Synonyms:
SHC1, shc1, Shc1, shc1.L
Insert length:
1425 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Mouse SHC1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
NCBI Accession:
NM_011368
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5107855
Datasheet
Catalog No. ABIN5107855
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
NCBI Accession:
NM_011368
Species:
Mouse
Synonyms:
SHC1, shc1, Shc1, shc1.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Shc1
Format:
Viral Particles
Storage:
-80 °C
Rat SHC1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
NCBI Accession:
NM_001164060
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5107857
Datasheet
Catalog No. ABIN5107857
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
NCBI Accession:
NM_001164060
Species:
Rat
Synonyms:
SHC1, shc1, Shc1, shc1.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Shc1
Format:
Viral Particles
Storage:
-80 °C
Human SHC1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
NCBI Accession:
NM_001130040
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5107853
Datasheet
Catalog No. ABIN5107853
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
NCBI Accession:
NM_001130040
Species:
Human
Synonyms:
SHC1, shc1, Shc1, shc1.L
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of SHC1
Format:
Viral Particles
Storage:
-80 °C
Human SHC1 cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4840024
Datasheet
Catalog No. ABIN4840024
Type:
cDNA
Application:
Cloning
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
Species:
Human
Synonyms:
SHC1, shc1, Shc1, shc1.L
Insert length:
1425 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human SHC1 cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4624553
Datasheet
Catalog No. ABIN4624553
Type:
cDNA
Application:
Cloning
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
Species:
Human
Synonyms:
SHC1, shc1, Shc1, shc1.L
Insert length:
1425 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human SHC1 cDNA Clone in Mammalian Expression Vector (His tag)
cDNA PExp Mammalian Expression Vector pPM-C-His Kanamycin CMV Promoter His tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-His
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
His tag
Expression:
Stable, Transient
Catalog No. ABIN4415996
Datasheet
Catalog No. ABIN4415996
Type:
cDNA
Application:
Protein Expression
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
Species:
Human
Synonyms:
SHC1, shc1, Shc1, shc1.L
Insert length:
1425 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-His
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
His tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human SHC1 cDNA Clone in Bacterial Expression Vector (His-MBP)
cDNA Clon Bacterial Expression Vector pPB-His-MBP Kanamycin T7 Promoter His-MBP Transient
Type:
cDNA
Application:
Cloning
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Catalog No. ABIN4710893
Datasheet
Catalog No. ABIN4710893
Type:
cDNA
Application:
Cloning
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
Species:
Human
Synonyms:
SHC1, shc1, Shc1, shc1.L
Insert length:
1425 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Sequencing Primer:
  • MBP Forward primer: 5'-CGCAGATGTCCGCTTTCTGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Mouse SHC1 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
NCBI Accession:
NM_011368
Species:
Mouse
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5734738
Datasheet
Catalog No. ABIN5734738
Type:
ORF
Application:
Cloning
Gene:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1)
NCBI Accession:
NM_011368
Species:
Mouse
Synonyms:
SHC1, shc1, Shc1, shc1.L
Insert length:
1410 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
    • Rat
    • Mouse
  • Cited in publications
  • Application
    • Protein Expression (PExp)
    • Cloning (Clon)
    • RNA Interference (RNAi)
    • Genome Editing with Engineered Nucleases (GEEN)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • Myc-DYKDDDDK Tag
    • His tag
    • DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • RFP tag
  • Vector Backbone
    • pCMV6-Entry
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-AC-GFP
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pcDNA3.1+C-(K)-DYK
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pRS
    • pCMV6-XL6
    • pCas-Guide
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pRFP-C-RS
    • pDONR223
  • Vector
    • Mammalian Expression Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
    • Gateway Cloning Vector
  • Insert
    • cDNA
    • ORF
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • CMV Promoter
    • U6 Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
    • SP6 Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to SHC1

  • SHC adaptor protein 1 (SHC1)
  • Shc1p (SHC1)
  • squalene--hopene cyclase (shc1)
  • SHC adaptor protein 1 (Shc1)
  • SHC (Src homology 2 domain containing) transforming protein 1 (shc1)
  • SHC (Src homology 2 domain containing) transforming protein 1 L homeolog (shc1.L)
  • src homology 2 domain-containing transforming protein C1 (Shc1)
  • p66
  • P66shc
  • p66shc
  • SHC
  • shc
  • Shc
  • SHC1
  • SHCA
  • ShcA
  • si:dkey-246i14.4
  • wu:fc10h03

Gene-IDs for different species

Protein level used designations for SHC1

  • SHC (Src homology 2 domain containing) transforming protein 1
  • Shc1p
  • Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
  • squalene--hopene cyclase
  • SH2 domain protein C1
  • SHC-transforming protein 1
  • src homology 2 domain-containing-transforming protein C1
  • SHC-transforming protein 1-like
  • SHC (Src homology 2 domain-containing) transforming protein 1
  • SHC-transforming protein 3
  • SHC-transforming protein A
  • src homology 2 domain-containing transforming protein C1
  • p60Shc
  • src homology collagen
  • adaptor protein SHC
Other products related to SHC1 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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