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SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain, SIGIRR)

Short Description: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity).
More information related to gene SIGIRR.

Products related to SIGIRR Gene:

58 results :

Human SIGIRR cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4481103
Datasheet
Catalog No. ABIN4481103
Type:
cDNA
Application:
Protein Expression
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
Species:
Human
Synonyms:
SIGIRR, Sigirr, sigirr
Insert length:
1233 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Rat SIGIRR CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
NCBI Accession:
NM_001024887
Species:
Rat
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5267823
Datasheet
Catalog No. ABIN5267823
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
NCBI Accession:
NM_001024887
Species:
Rat
Synonyms:
SIGIRR, Sigirr, sigirr
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Sigirr
Format:
Viral Particles
Storage:
-80 °C
Mouse SIGIRR CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
NCBI Accession:
NM_023059
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5267821
Datasheet
Catalog No. ABIN5267821
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
NCBI Accession:
NM_023059
Species:
Mouse
Synonyms:
SIGIRR, Sigirr, sigirr
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Sigirr
Format:
Viral Particles
Storage:
-80 °C
Human SIGIRR CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
NCBI Accession:
NM_021805
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5267819
Datasheet
Catalog No. ABIN5267819
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
NCBI Accession:
NM_021805
Species:
Human
Synonyms:
SIGIRR, Sigirr, sigirr
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of SIGIRR
Format:
Viral Particles
Storage:
-80 °C
Rat SIGIRR CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
NCBI Accession:
NM_001024887
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5152263
Datasheet
Catalog No. ABIN5152263
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
NCBI Accession:
NM_001024887
Species:
Rat
Synonyms:
SIGIRR, Sigirr, sigirr
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Sigirr
Format:
Viral Particles
Storage:
-80 °C
Mouse SIGIRR CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
NCBI Accession:
NM_023059
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5152261
Datasheet
Catalog No. ABIN5152261
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
NCBI Accession:
NM_023059
Species:
Mouse
Synonyms:
SIGIRR, Sigirr, sigirr
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Sigirr
Format:
Viral Particles
Storage:
-80 °C
Human SIGIRR CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
NCBI Accession:
NM_021805
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5152259
Datasheet
Catalog No. ABIN5152259
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
NCBI Accession:
NM_021805
Species:
Human
Synonyms:
SIGIRR, Sigirr, sigirr
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of SIGIRR
Format:
Viral Particles
Storage:
-80 °C
Human SIGIRR cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4840062
Datasheet
Catalog No. ABIN4840062
Type:
cDNA
Application:
Cloning
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
Species:
Human
Synonyms:
SIGIRR, Sigirr, sigirr
Insert length:
1233 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human SIGIRR cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4624574
Datasheet
Catalog No. ABIN4624574
Type:
cDNA
Application:
Cloning
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
Species:
Human
Synonyms:
SIGIRR, Sigirr, sigirr
Insert length:
1233 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human SIGIRR cDNA Clone in Mammalian Expression Vector (His tag)
cDNA PExp Mammalian Expression Vector pPM-C-His Kanamycin CMV Promoter His tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-His
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
His tag
Expression:
Stable, Transient
Catalog No. ABIN4416017
Datasheet
Catalog No. ABIN4416017
Type:
cDNA
Application:
Protein Expression
Gene:
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR)
Species:
Human
Synonyms:
SIGIRR, Sigirr, sigirr
Insert length:
1233 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-His
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
His tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • OriGene
    • antibodies-online
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
    • Rat
    • Mouse
  • Application
    • Protein Expression (PExp)
    • Genome Editing with Engineered Nucleases (GEEN)
    • RNA Interference (RNAi)
    • Cloning (Clon)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • Myc-DYKDDDDK Tag
    • His tag
    • HA tag
    • His-GST
    • His-MBP
    • DYKDDDDK Tag
    • RFP tag
  • Vector Backbone
    • pCMV6-Entry
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-AC-GFP
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pRS
    • pCas-Guide
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pCMV6-AC
    • pDONR223
    • pRFP-C-RS
    • pcDNA3.1+C-(K)-DYK
  • Vector
    • Mammalian Expression Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Gateway Cloning Vector
  • Insert
    • cDNA
    • ORF
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to SIGIRR

  • single Ig and TIR domain containing (SIGIRR)
  • single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr)
  • single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (sigirr)
  • single Ig and TIR domain containing (Sigirr)
  • AI256711
  • RGD1306732
  • sc:d148
  • TIR8

Gene-IDs for different species

Protein level used designations for SIGIRR

  • single Ig IL-1-related receptor
  • single Ig IL-1R-related molecule
  • single immunoglobulin domain IL1R1 related
  • single immunoglobulin domain-containing IL1R-related protein
  • toll/interleukin-1 receptor 8
  • single Ig IL-1 receptor related protein
  • single Ig IL-1R-related protein
  • TIR8
Other products related to SIGIRR such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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