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SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2, SMURF2)

Short Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).
More information related to gene SMURF2.

Products related to SMURF2 Gene:

56 results :

Human SMURF2 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_022739
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5754353
Datasheet
Catalog No. ABIN5754353
Type:
ORF
Application:
Cloning
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_022739
Species:
Human
Synonyms:
SMURF2, smurf2, Smurf2, smurf2.S
Insert length:
2247 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Mouse SMURF2 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_025481
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5261221
Datasheet
Catalog No. ABIN5261221
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_025481
Species:
Mouse
Synonyms:
SMURF2, smurf2, Smurf2, smurf2.S
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Smurf2
Format:
Viral Particles
Storage:
-80 °C
Rat SMURF2 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_001107061
Species:
Rat
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5261223
Datasheet
Catalog No. ABIN5261223
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_001107061
Species:
Rat
Synonyms:
SMURF2, smurf2, Smurf2, smurf2.S
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Smurf2
Format:
Viral Particles
Storage:
-80 °C
Human SMURF2 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_022739
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5261219
Datasheet
Catalog No. ABIN5261219
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_022739
Species:
Human
Synonyms:
SMURF2, smurf2, Smurf2, smurf2.S
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of SMURF2
Format:
Viral Particles
Storage:
-80 °C
Rat SMURF2 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_001107061
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5145708
Datasheet
Catalog No. ABIN5145708
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_001107061
Species:
Rat
Synonyms:
SMURF2, smurf2, Smurf2, smurf2.S
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Smurf2
Format:
Viral Particles
Storage:
-80 °C
Mouse SMURF2 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_025481
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5145706
Datasheet
Catalog No. ABIN5145706
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_025481
Species:
Mouse
Synonyms:
SMURF2, smurf2, Smurf2, smurf2.S
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Smurf2
Format:
Viral Particles
Storage:
-80 °C
Human SMURF2 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_022739
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5145704
Datasheet
Catalog No. ABIN5145704
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_022739
Species:
Human
Synonyms:
SMURF2, smurf2, Smurf2, smurf2.S
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of SMURF2
Format:
Viral Particles
Storage:
-80 °C
Mouse SMURF2 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_025481
Species:
Mouse
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5754354
Datasheet
Catalog No. ABIN5754354
Type:
ORF
Application:
Cloning
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_025481
Species:
Mouse
Synonyms:
SMURF2, smurf2, Smurf2, smurf2.S
Insert length:
2247 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Rat SMURF2 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_001107061
Species:
Rat
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5754355
Datasheet
Catalog No. ABIN5754355
Type:
ORF
Application:
Cloning
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_001107061
Species:
Rat
Synonyms:
SMURF2, smurf2, Smurf2, smurf2.S
Insert length:
2247 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human SMURF2 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_022739
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4490429
Datasheet
Catalog No. ABIN4490429
Type:
cDNA
Application:
Protein Expression
Gene:
SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
NCBI Accession:
NM_022739
Species:
Human
Synonyms:
SMURF2, smurf2, Smurf2, smurf2.S
Insert length:
870 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
  • Reactivity
    • Human
    • Rat
    • Mouse
  • Cited in publications
  • Application
    • Protein Expression (PExp)
    • Genome Editing with Engineered Nucleases (GEEN)
    • RNA Interference (RNAi)
    • Cloning (Clon)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • His tag
    • Myc-DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • DYKDDDDK Tag
    • RFP tag
  • Vector Backbone
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-Entry
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pRS
    • pCas-Guide
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pCMV6-AC-GFP
    • pCMV6-XL6
    • pRFP-C-RS
    • pcDNA3.1+C-(K)-DYK
  • Vector
    • Lentiviral Vector
    • Mammalian Expression Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
  • Insert
    • cDNA
    • ORF
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • T7 Promoter
    • PGK Promoter
    • SFFV Promoter
    • Enhanced CMV Promoter
    • SP6 Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to SMURF2

  • SMAD specific E3 ubiquitin protein ligase 2 (SMURF2)
  • SMAD specific E3 ubiquitin protein ligase 2 (smurf2)
  • SMAD specific E3 ubiquitin protein ligase 2 (Smurf2)
  • SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S)
  • 2810411E22Rik
  • AI558114
  • AI649275
  • RGD1310067
  • SMURF2
  • wu:fb82a11
  • wu:fc41c02

Gene-IDs for different species

Protein level used designations for SMURF2

  • SMAD specific E3 ubiquitin protein ligase 2
  • E3 ubiquitin-protein ligase SMURF2-like
  • e3 ubiquitin-protein ligase SMURF2-like
  • E3 ubiquitin ligase SMURF2
  • E3 ubiquitin-protein ligase SMURF2
  • SMAD ubiquitination regulatory factor 2
  • SMAD-specific E3 ubiquitin-protein ligase 2
  • hSMURF2
  • E3 ubiquitin ligase Smurf2
Other products related to SMURF2 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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