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VHL (Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase, VHL)

Short Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
More information related to gene VHL.

Products related to VHL Gene:

72 results :

Human VHL ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5763689
Datasheet
Catalog No. ABIN5763689
Type:
ORF
Application:
Cloning
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
Species:
Human
Synonyms:
VHL, Vhl, vhl, CpipJ_CPIJ009992
Insert length:
519 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human VHL cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4483017
Datasheet
Catalog No. ABIN4483017
Type:
cDNA
Application:
Protein Expression
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
Species:
Human
Synonyms:
VHL, Vhl, vhl, CpipJ_CPIJ009992
Insert length:
519 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Mouse VHL CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
NCBI Accession:
NM_009507
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5279373
Datasheet
Catalog No. ABIN5279373
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
NCBI Accession:
NM_009507
Species:
Mouse
Synonyms:
VHL, Vhl, vhl, CpipJ_CPIJ009992
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Vhl
Format:
Viral Particles
Storage:
-80 °C
Human VHL CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
NCBI Accession:
NM_198156
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5279370
Datasheet
Catalog No. ABIN5279370
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
NCBI Accession:
NM_198156
Species:
Human
Synonyms:
VHL, Vhl, vhl, CpipJ_CPIJ009992
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of VHL
Format:
Viral Particles
Storage:
-80 °C
Rat VHL CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
NCBI Accession:
NM_052801
Species:
Rat
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5279377
Datasheet
Catalog No. ABIN5279377
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
NCBI Accession:
NM_052801
Species:
Rat
Synonyms:
VHL, Vhl, vhl, CpipJ_CPIJ009992
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Vhl
Format:
Viral Particles
Storage:
-80 °C
Mouse VHL CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
NCBI Accession:
NM_009507
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5279375
Datasheet
Catalog No. ABIN5279375
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
NCBI Accession:
NM_009507
Species:
Mouse
Synonyms:
VHL, Vhl, vhl, CpipJ_CPIJ009992
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Vhl
Format:
Viral Particles
Storage:
-80 °C
Mouse VHL CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
NCBI Accession:
NM_009507
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5279374
Datasheet
Catalog No. ABIN5279374
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
NCBI Accession:
NM_009507
Species:
Mouse
Synonyms:
VHL, Vhl, vhl, CpipJ_CPIJ009992
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Vhl
Format:
Viral Particles
Storage:
-80 °C
Human VHL CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
NCBI Accession:
NM_198156
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5279371
Datasheet
Catalog No. ABIN5279371
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
NCBI Accession:
NM_198156
Species:
Human
Synonyms:
VHL, Vhl, vhl, CpipJ_CPIJ009992
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of VHL
Format:
Viral Particles
Storage:
-80 °C
Human VHL CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
NCBI Accession:
NM_198156
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5279369
Datasheet
Catalog No. ABIN5279369
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
NCBI Accession:
NM_198156
Species:
Human
Synonyms:
VHL, Vhl, vhl, CpipJ_CPIJ009992
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of VHL
Format:
Viral Particles
Storage:
-80 °C
Human VHL CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5279367
Datasheet
Catalog No. ABIN5279367
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL)
Species:
Human
Synonyms:
VHL, Vhl, vhl, CpipJ_CPIJ009992
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of RCA1
Format:
Viral Particles
Storage:
-80 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
    • Mouse
    • Rat
  • Cited in publications
  • Application
    • Protein Expression (PExp)
    • Genome Editing with Engineered Nucleases (GEEN)
    • RNA Interference (RNAi)
    • Cloning (Clon)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • Myc-DYKDDDDK Tag
    • His tag
    • HA tag
    • His-GST
    • His-MBP
    • DYKDDDDK Tag
    • RFP tag
  • Vector Backbone
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pLenti-U6-sgRNA-PGK-Neo
    • pCMV6-Entry
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pRS
    • pCMV6-AC-GFP
    • pCMV6-XL5
    • pCas-Guide
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pRFP-C-RS
    • pcDNA3.1+C-(K)-DYK
    • pDONR223
  • Vector
    • Lentiviral Vector
    • Mammalian Expression Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
    • Gateway Cloning Vector
  • Insert
    • cDNA
    • ORF
    • gRNA + Cas9
    • shRNA
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Ampicillin
    • Kanamycin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Puromycin
    • Neomycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • SFFV Promoter
    • T7 Promoter
    • PGK Promoter
    • Enhanced CMV Promoter
  • Format
    • Lyophilized
    • Viral Particles
    • Liquid

Synonyms and alternative names related to VHL

  • von Hippel-Lindau tumor suppressor (VHL)
  • von Hippel-Lindau (Vhl)
  • von Hippel-Lindau tumor suppressor (vhl)
  • von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL)
  • von Hippel-Lindau disease tumor suppressor (CpipJ_CPIJ009992)
  • von Hippel-Lindau tumor suppressor (Vhl)
  • BcDNA:RH61560
  • CG13221
  • d-VHL
  • d-vhl
  • Dmel\\CG13221
  • dmVHL
  • DVhl
  • Dvhl
  • dVHL
  • HRCA1
  • hrca1
  • pVHL
  • RCA1
  • rca1
  • VHL
  • vhl
  • VHL1
  • vhl1
  • Vhlh
  • zgc:158722

Gene-IDs for different species

Protein level used designations for VHL

  • elongin binding protein
  • protein G7
  • von Hippel-Lindau disease tumor suppressor
  • CG13221-PA
  • CG13221-PB
  • Vhl-PA
  • Vhl-PB
  • von hippel lindau
  • von hippel lindau protein
  • pVHL
  • von Hippel-Lindau tumor suppressor
  • von Hippel-Lindau syndrome homolog
  • von Hippel-Lindau syndrome protein homolog
  • Von Hippel-Lindau disease tumor suppressor
Other products related to VHL such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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